摘要
The long-lasting problematic low yield in the D-ring cyclization of ellipticine (1a) was dramatically improved through N-(1,4-dimethylcarbazol-3- ylmethyl)-N-tosylaminoacetaldehyde diethyl acetal with microwave irradiation. The overall yield of 1a starting from indole was significantly increased by 25-fold. This new approach is superior to reported methods in yields and, reaction time, and it provides efficient access to a broad spectrum of ellipticine derivatives.
原文 | 英語 |
---|---|
頁(從 - 到) | 454-458 |
頁數 | 5 |
期刊 | Journal of Heterocyclic Chemistry |
卷 | 47 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 3月 2010 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 有機化學