Efficient microwave-assisted synthesis of ellipticine through N-(1,4-dimethyl-9h-carbazol-3-ylmethyl)-n-tosylaminoacetaldehyde diethyl acetal

Hsueh Yun Lee, Grace Shiahuy Chen, Chien Shu Chen, Ji Wang Cherna

研究成果: 雜誌貢獻文章

18 引文 斯高帕斯(Scopus)

摘要

The long-lasting problematic low yield in the D-ring cyclization of ellipticine (1a) was dramatically improved through N-(1,4-dimethylcarbazol-3- ylmethyl)-N-tosylaminoacetaldehyde diethyl acetal with microwave irradiation. The overall yield of 1a starting from indole was significantly increased by 25-fold. This new approach is superior to reported methods in yields and, reaction time, and it provides efficient access to a broad spectrum of ellipticine derivatives.

原文英語
頁(從 - 到)454-458
頁數5
期刊Journal of Heterocyclic Chemistry
47
發行號2
DOIs
出版狀態已發佈 - 三月 2010
對外發佈Yes

    指紋

ASJC Scopus subject areas

  • Organic Chemistry

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