摘要
The long-lasting problematic low yield in the D-ring cyclization of ellipticine (1a) was dramatically improved through N-(1,4-dimethylcarbazol-3- ylmethyl)-N-tosylaminoacetaldehyde diethyl acetal with microwave irradiation. The overall yield of 1a starting from indole was significantly increased by 25-fold. This new approach is superior to reported methods in yields and, reaction time, and it provides efficient access to a broad spectrum of ellipticine derivatives.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 454-458 |
| 頁數 | 5 |
| 期刊 | Journal of Heterocyclic Chemistry |
| 卷 | 47 |
| 發行號 | 2 |
| DOIs | |
| 出版狀態 | 已發佈 - 三月 2010 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Organic Chemistry
引用此文
Efficient microwave-assisted synthesis of ellipticine through N-(1,4-dimethyl-9h-carbazol-3-ylmethyl)-n-tosylaminoacetaldehyde diethyl acetal. / Lee, Hsueh Yun; Chen, Grace Shiahuy; Chen, Chien Shu; Cherna, Ji Wang.
於: Journal of Heterocyclic Chemistry, 卷 47, 編號 2, 03.2010, p. 454-458.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Efficient microwave-assisted synthesis of ellipticine through N-(1,4-dimethyl-9h-carbazol-3-ylmethyl)-n-tosylaminoacetaldehyde diethyl acetal
AU - Lee, Hsueh Yun
AU - Chen, Grace Shiahuy
AU - Chen, Chien Shu
AU - Cherna, Ji Wang
PY - 2010/3
Y1 - 2010/3
N2 - The long-lasting problematic low yield in the D-ring cyclization of ellipticine (1a) was dramatically improved through N-(1,4-dimethylcarbazol-3- ylmethyl)-N-tosylaminoacetaldehyde diethyl acetal with microwave irradiation. The overall yield of 1a starting from indole was significantly increased by 25-fold. This new approach is superior to reported methods in yields and, reaction time, and it provides efficient access to a broad spectrum of ellipticine derivatives.
AB - The long-lasting problematic low yield in the D-ring cyclization of ellipticine (1a) was dramatically improved through N-(1,4-dimethylcarbazol-3- ylmethyl)-N-tosylaminoacetaldehyde diethyl acetal with microwave irradiation. The overall yield of 1a starting from indole was significantly increased by 25-fold. This new approach is superior to reported methods in yields and, reaction time, and it provides efficient access to a broad spectrum of ellipticine derivatives.
UR - http://www.scopus.com/inward/record.url?scp=77950330643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950330643&partnerID=8YFLogxK
U2 - 10.1002/jhet.319
DO - 10.1002/jhet.319
M3 - Article
AN - SCOPUS:77950330643
VL - 47
SP - 454
EP - 458
JO - Journal of Heterocyclic Chemistry
JF - Journal of Heterocyclic Chemistry
SN - 0022-152X
IS - 2
ER -