Efficacy of postoperative polymyxin B hemoperfusion in secondary peritonitis patients with septic shock: A propensity-matched analysis

Kuo Ching Yuan, Shang Yu Wang, Ming Chin Yu, Yu Pao Hsu, Heng Chih Pan, Yung Chang Chen

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Introduction: Severe sepsis and septic shock is still a challenge. Polymyxin B hemoperfusion (PMX) is a device designed to remove circulating endotoxin by adsorption, which is reported to improve treatment outcomes. This study aimed to further verify the efficacy of PMX on postoperative, peritonitis, septic shock patients. Methods: This study prospectively analyzed 20 of 155 patients who presented with postoperative septic shock and were treated with PMX in a single institute during the period March 2013 to September 2014 (Clinical Trial Protocol number: ChiCTR-ONC-16008160). A control group (53 patients) was recruited from our own 2012 database using the propensity-matching score method. The data collection includes demographic data, postoperative organ dysfunction status, disease severity and treatment result. Results: The 2 groups (treatment vs. control) were similar in demographic data, organ dysfunction status and disease severity. PMX use provides benefits for recovery of hemodynamic status and many other aspects, including better survival, but is not statistically significant. For survival factor analysis, PMX use is also not significant for patient survival in our study. Conclusions: PMX provided some benefits to patients in the treatment for peritonitis septic shock. An improvement in hemodynamic status was mostly observed. Our study also supports the finding that PMX used as an auxiliary treatment provides improved survival but is not statistically significant, possibly due to the small sample size with multiple comorbidities.

原文英語
頁(從 - 到)603-610
頁數8
期刊International Journal of Artificial Organs
39
發行號12
DOIs
出版狀態已發佈 - 十二月 1 2016
對外發佈

ASJC Scopus subject areas

  • 生物工程
  • 醫藥(雜項)
  • 生物材料
  • 生物醫學工程

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