Efficacy of hepatitis B vaccine boosters among neonatally vaccinated university freshmen in Taiwan

Fu-Hsiung Su, Fang Yeh Chu, Chyi-Huey Bai, Yu-Shiang Lin, Yu-Mei Hsueh, Fung Chang Sung, Chih-Ching Yeh

研究成果: 雜誌貢獻文章

17 引文 (Scopus)

摘要

Background & Aims Long-term protection against hepatitis B virus (HBV) after vaccination remains widely debated. We evaluated the efficacy of a modified 3-dose booster protocol in neonatally vaccinated university students in Taiwan. Methods Changes in the levels of antibodies to the hepatitis B surface antigen (anti-HBs) were examined in 250 university students over a 3-year period. Group A (n = 39) lacked seroprotective levels of anti-HBs, and declined to receive a booster dose of the HBV vaccine. Group B (n = 128) lacked seroprotective levels of anti-HBs, and received booster doses of the HBV vaccine according to a modified 3-dose booster protocol. Group C (n = 83) possessed seroprotective levels of anti-HBs, and did not receive a booster dose. Results The levels of seroprotective anti-HBs increased in 12.8% of Group A and 14.5% of Group C, suggesting that our entire cohort had experienced booster effects from natural HBV exposure. However, no new HBV infections were observed, and 53.9% of Group B maintained protective levels of anti-HBs during the follow-up period. Conclusions The use of the modified 3-dose booster protocol induced significant long-term increases in the titer of anti-HBs in over 50% of the neonatally vaccinated participants with previously non-protective titers. However, in the absence of a vaccine booster, some neonatally vaccinated people with low anti-HBs titers may nonetheless produce anamnestic responses to HBV upon exposure, suggesting that protection from neonatal vaccination may persist, despite low titers of anti-HBs.
原文英語
頁(從 - 到)684-689
頁數6
期刊Journal of Hepatology
58
發行號4
DOIs
出版狀態已發佈 - 四月 2013

指紋

Hepatitis B Vaccines
Taiwan
Hepatitis B virus
Vaccination
Students
Virus Diseases
Hepatitis B Surface Antigens
Vaccines
Antibodies

ASJC Scopus subject areas

  • Hepatology

引用此文

Efficacy of hepatitis B vaccine boosters among neonatally vaccinated university freshmen in Taiwan. / Su, Fu-Hsiung; Chu, Fang Yeh; Bai, Chyi-Huey; Lin, Yu-Shiang; Hsueh, Yu-Mei; Sung, Fung Chang; Yeh, Chih-Ching.

於: Journal of Hepatology, 卷 58, 編號 4, 04.2013, p. 684-689.

研究成果: 雜誌貢獻文章

Su, Fu-Hsiung ; Chu, Fang Yeh ; Bai, Chyi-Huey ; Lin, Yu-Shiang ; Hsueh, Yu-Mei ; Sung, Fung Chang ; Yeh, Chih-Ching. / Efficacy of hepatitis B vaccine boosters among neonatally vaccinated university freshmen in Taiwan. 於: Journal of Hepatology. 2013 ; 卷 58, 編號 4. 頁 684-689.
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title = "Efficacy of hepatitis B vaccine boosters among neonatally vaccinated university freshmen in Taiwan",
abstract = "Background & Aims Long-term protection against hepatitis B virus (HBV) after vaccination remains widely debated. We evaluated the efficacy of a modified 3-dose booster protocol in neonatally vaccinated university students in Taiwan. Methods Changes in the levels of antibodies to the hepatitis B surface antigen (anti-HBs) were examined in 250 university students over a 3-year period. Group A (n = 39) lacked seroprotective levels of anti-HBs, and declined to receive a booster dose of the HBV vaccine. Group B (n = 128) lacked seroprotective levels of anti-HBs, and received booster doses of the HBV vaccine according to a modified 3-dose booster protocol. Group C (n = 83) possessed seroprotective levels of anti-HBs, and did not receive a booster dose. Results The levels of seroprotective anti-HBs increased in 12.8{\%} of Group A and 14.5{\%} of Group C, suggesting that our entire cohort had experienced booster effects from natural HBV exposure. However, no new HBV infections were observed, and 53.9{\%} of Group B maintained protective levels of anti-HBs during the follow-up period. Conclusions The use of the modified 3-dose booster protocol induced significant long-term increases in the titer of anti-HBs in over 50{\%} of the neonatally vaccinated participants with previously non-protective titers. However, in the absence of a vaccine booster, some neonatally vaccinated people with low anti-HBs titers may nonetheless produce anamnestic responses to HBV upon exposure, suggesting that protection from neonatal vaccination may persist, despite low titers of anti-HBs.",
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N2 - Background & Aims Long-term protection against hepatitis B virus (HBV) after vaccination remains widely debated. We evaluated the efficacy of a modified 3-dose booster protocol in neonatally vaccinated university students in Taiwan. Methods Changes in the levels of antibodies to the hepatitis B surface antigen (anti-HBs) were examined in 250 university students over a 3-year period. Group A (n = 39) lacked seroprotective levels of anti-HBs, and declined to receive a booster dose of the HBV vaccine. Group B (n = 128) lacked seroprotective levels of anti-HBs, and received booster doses of the HBV vaccine according to a modified 3-dose booster protocol. Group C (n = 83) possessed seroprotective levels of anti-HBs, and did not receive a booster dose. Results The levels of seroprotective anti-HBs increased in 12.8% of Group A and 14.5% of Group C, suggesting that our entire cohort had experienced booster effects from natural HBV exposure. However, no new HBV infections were observed, and 53.9% of Group B maintained protective levels of anti-HBs during the follow-up period. Conclusions The use of the modified 3-dose booster protocol induced significant long-term increases in the titer of anti-HBs in over 50% of the neonatally vaccinated participants with previously non-protective titers. However, in the absence of a vaccine booster, some neonatally vaccinated people with low anti-HBs titers may nonetheless produce anamnestic responses to HBV upon exposure, suggesting that protection from neonatal vaccination may persist, despite low titers of anti-HBs.

AB - Background & Aims Long-term protection against hepatitis B virus (HBV) after vaccination remains widely debated. We evaluated the efficacy of a modified 3-dose booster protocol in neonatally vaccinated university students in Taiwan. Methods Changes in the levels of antibodies to the hepatitis B surface antigen (anti-HBs) were examined in 250 university students over a 3-year period. Group A (n = 39) lacked seroprotective levels of anti-HBs, and declined to receive a booster dose of the HBV vaccine. Group B (n = 128) lacked seroprotective levels of anti-HBs, and received booster doses of the HBV vaccine according to a modified 3-dose booster protocol. Group C (n = 83) possessed seroprotective levels of anti-HBs, and did not receive a booster dose. Results The levels of seroprotective anti-HBs increased in 12.8% of Group A and 14.5% of Group C, suggesting that our entire cohort had experienced booster effects from natural HBV exposure. However, no new HBV infections were observed, and 53.9% of Group B maintained protective levels of anti-HBs during the follow-up period. Conclusions The use of the modified 3-dose booster protocol induced significant long-term increases in the titer of anti-HBs in over 50% of the neonatally vaccinated participants with previously non-protective titers. However, in the absence of a vaccine booster, some neonatally vaccinated people with low anti-HBs titers may nonetheless produce anamnestic responses to HBV upon exposure, suggesting that protection from neonatal vaccination may persist, despite low titers of anti-HBs.

KW - Antibody

KW - Follow-up

KW - Hepatitis B

KW - Protective immunity

KW - Vaccination

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