Efficacy of fexofenadine in isolated rat tracheas

Wen Sen Lai, Yuan Yung Lin, Yueng Hsiang Chu, Chih Hung Wang, Hsing Won Wang

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Objectives: Histamine is an important chemical mediator in both nasal and bronchial inflammation in patients with allergic rhinitis and asthma. The effect of histamine receptor-1 antagonists on nasal mucosa in vivo is well known, however, the effect on tracheal smooth muscle has rarely been explored. The purpose of this study was to determine the effects of fexofenadine on isolated tracheal smooth muscle in vitro. Methods: Six tracheal strips were used for each experiment, and one untreated strip served as a control. We examined the effectiveness of fexofenadine on isolated rat tracheal smooth muscle by testing the effect on: 1) tracheal smooth muscle resting tension; 2) contraction caused by 10-6 M methacholine as a parasympathetic mimetic; and 3) electrically induced tracheal smooth muscle contractions. Results: The results indicated that addition of methacholine caused the trachea to contract in a dose-dependent manner. The addition of fexofenadine at a dose of 10-4 M elicited a significant relaxation response compared to 10-6 M methacholine-induced contraction. There were no detectable changes in the peak tension of electrical field stimulation-induced contractions in the fexofenadine group. Conclusion: High concentrations of fexofenadine had an anti-cholinergic effect. In addition to diminishing histamine-mediated allergic symptoms, fexofenadine may have a potentially therapeutic implication in alleviating asthma-related symptoms due to reducing methacholine-induced contractions of tracheal smooth muscle though these aspects were not studied.
原文英語
頁(從 - 到)376-380
頁數5
期刊Rhinology
51
發行號4
DOIs
出版狀態已發佈 - 2013

指紋

fexofenadine
Trachea
Smooth Muscle
Methacholine Chloride
Histamine
Asthma
Histamine Receptors
Muscle Tonus
Nasal Mucosa
Cholinergic Antagonists
Muscle Contraction
Nose
Cholinergic Agents
Electric Stimulation

ASJC Scopus subject areas

  • Otorhinolaryngology

引用此文

Lai, W. S., Lin, Y. Y., Chu, Y. H., Wang, C. H., & Wang, H. W. (2013). Efficacy of fexofenadine in isolated rat tracheas. Rhinology, 51(4), 376-380. https://doi.org/10.4193/Rhino12.213

Efficacy of fexofenadine in isolated rat tracheas. / Lai, Wen Sen; Lin, Yuan Yung; Chu, Yueng Hsiang; Wang, Chih Hung; Wang, Hsing Won.

於: Rhinology, 卷 51, 編號 4, 2013, p. 376-380.

研究成果: 雜誌貢獻文章

Lai, WS, Lin, YY, Chu, YH, Wang, CH & Wang, HW 2013, 'Efficacy of fexofenadine in isolated rat tracheas', Rhinology, 卷 51, 編號 4, 頁 376-380. https://doi.org/10.4193/Rhino12.213
Lai, Wen Sen ; Lin, Yuan Yung ; Chu, Yueng Hsiang ; Wang, Chih Hung ; Wang, Hsing Won. / Efficacy of fexofenadine in isolated rat tracheas. 於: Rhinology. 2013 ; 卷 51, 編號 4. 頁 376-380.
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N2 - Objectives: Histamine is an important chemical mediator in both nasal and bronchial inflammation in patients with allergic rhinitis and asthma. The effect of histamine receptor-1 antagonists on nasal mucosa in vivo is well known, however, the effect on tracheal smooth muscle has rarely been explored. The purpose of this study was to determine the effects of fexofenadine on isolated tracheal smooth muscle in vitro. Methods: Six tracheal strips were used for each experiment, and one untreated strip served as a control. We examined the effectiveness of fexofenadine on isolated rat tracheal smooth muscle by testing the effect on: 1) tracheal smooth muscle resting tension; 2) contraction caused by 10-6 M methacholine as a parasympathetic mimetic; and 3) electrically induced tracheal smooth muscle contractions. Results: The results indicated that addition of methacholine caused the trachea to contract in a dose-dependent manner. The addition of fexofenadine at a dose of 10-4 M elicited a significant relaxation response compared to 10-6 M methacholine-induced contraction. There were no detectable changes in the peak tension of electrical field stimulation-induced contractions in the fexofenadine group. Conclusion: High concentrations of fexofenadine had an anti-cholinergic effect. In addition to diminishing histamine-mediated allergic symptoms, fexofenadine may have a potentially therapeutic implication in alleviating asthma-related symptoms due to reducing methacholine-induced contractions of tracheal smooth muscle though these aspects were not studied.

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