Efficacy and safety of traction-assisted endoscopic submucosal dissection: A meta-regression of randomized clinical trials

Ying Fong Su, Sheng Wei Cheng, Chun Chao Chang, Yi No Kang

研究成果: 雜誌貢獻回顧型文獻同行評審

5 引文 斯高帕斯(Scopus)

摘要

Background Endoscopic submucosal dissection (ESD) is widely used to treat gastrointestinal lesions. A tractionassisted (TA) strategy has been recently developed for ESD. In this study, we evaluated the safety and efficacy of TA-ESD compared with conventional ESD (C-ESD). Methods We searched PubMed, Embase, Web of Science, and the China National Knowledge Infrastructure to identify randomized clinical trials that compared TA-ESD and C-ESD. No filters for language or date of publication were used. Outcomes included complete resection rate, resected specimen size, procedure time, hemostasis usage (frequency), overall complication rate, perforation rate, and delayed bleeding rate. We used the mean difference (MD) for continuous outcomes in a random-effects model and Peto odds ratio (POR) for binary outcomes where any zero cell existed. Effect sizes and their 95% confidence intervals (CIs) were determined. Results 12 out of 929 identified articles, including 1499 patients, were analyzed. According to pooled results, TAESD produced similar R0 resections to C-ESD, but its procedure time (minutes) was shorter than that of C-ESD (MD - 16.02, 95 %CI - 22.71 to - 9.33). Moreover, TA-ESD had a lower complication rate (POR 0.47, 95%CI 0.29 to 0.76) and perforation rate (POR 0.24, 95 %CI 0.10 to 0.56) than CESD. A nonsignificant difference in delayed bleeding rate was observed, although there was a trend toward this being lower in TA-ESD than C-ESD (POR 0.90, 95 %CI 0.46 to 1.75, I2=12%). Conclusions The traction-assisted strategy improves safety and efficacy in the treatment of patients with ESD. However, we observed different effect sizes in the esophagus, stomach, and colorectum.

原文英語
頁(從 - 到)338-348
頁數11
期刊Endoscopy
52
發行號5
DOIs
出版狀態已發佈 - 5月 1 2020

ASJC Scopus subject areas

  • 消化內科

指紋

深入研究「Efficacy and safety of traction-assisted endoscopic submucosal dissection: A meta-regression of randomized clinical trials」主題。共同形成了獨特的指紋。

引用此