Effects of zinc deficiency on the vallate papillae and taste buds in rats

H. C. Chou, C. L. Chien, H. L. Huang, K. S. Lu

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20 引文 斯高帕斯(Scopus)


Background and Purpose: Zinc deficiency is associated with multiple clinical complications, including taste disturbance, anorexia, growth retardation, skin changes, and hypogonadism. We investigated the zinc-deficiency-induced morphologic changes in the vallate taste buds of weanling and young adult male Wistar rats. Methods: A total of 24 weanling and 30 young adult rats were used. Each age group was further divided into a control group fed a zinc-adequate (50 ppm) diet, a zinc-deficient (<1 ppm) diet group, and a zinc-adequate pair-fed group who were fed the same amount of food as that taken by the zinc-deficient group. Weanling rats were fed for 4 weeks and young adult rats were fed for 6 weeks. The morphometry and morphologic changes of vallate taste buds were analyzed using light and transmission electron microscopy. Results: Light microscopy revealed no significant difference in papilla size and morphology among the various groups. In both weanling and young adult rats in the zinc-deficient diet and pair-fed groups, the number of taste buds per papilla (per animal) and the average profile area of the taste bud were significantly smaller than those of the corresponding controls (p
頁(從 - 到)326-335
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
出版狀態已發佈 - 2001

ASJC Scopus subject areas

  • 醫藥 (全部)


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