TY - JOUR
T1 - Effects of Ultrasound on Osteotomy Healing in a Rabbit Fracture Model
AU - Lai, Chien Hung
AU - Chuang, Chiung Cheng
AU - Kuan-Jung Li, Jimmy
AU - Chen, Shih Ching
AU - Hong-Shong Chang, Walter
PY - 2011/10
Y1 - 2011/10
N2 - This study investigated the effects of ultrasound (US) at different frequencies on fracture healing over a three-week period in a rabbit fibular fracture model. Forty-five adult New Zealand White rabbits were divided into five groups: a control group and four groups treated with US frequencies of 0.5, 1.0, 1.5 and 2.0 MHz (0.5 W/cm 2, 200-μs burst, pulsed 1:4). After anesthesia, transverse osteotomy was performed on the fibula bone. This was followed by intravital staining and fluorescence microscopic examination of new bone formation and biomechanical tests of torsional stiffness at the osteotomy site. Results showed that total new bone formation and torsional stiffness of the fibula were greater in all US-treated groups than in the control group. No significant difference was found between any of the four US-treated groups. The US treatment also enhanced bone growth of the sham-treated contralateral fracture site. These results suggest that US treatment at 0.5, 1.0, 1.5 or 2.0 MHz can enhance fracture healing in a rabbit model. Furthermore, the effects of US on fracture healing at present parameters might not be confined locally.
AB - This study investigated the effects of ultrasound (US) at different frequencies on fracture healing over a three-week period in a rabbit fibular fracture model. Forty-five adult New Zealand White rabbits were divided into five groups: a control group and four groups treated with US frequencies of 0.5, 1.0, 1.5 and 2.0 MHz (0.5 W/cm 2, 200-μs burst, pulsed 1:4). After anesthesia, transverse osteotomy was performed on the fibula bone. This was followed by intravital staining and fluorescence microscopic examination of new bone formation and biomechanical tests of torsional stiffness at the osteotomy site. Results showed that total new bone formation and torsional stiffness of the fibula were greater in all US-treated groups than in the control group. No significant difference was found between any of the four US-treated groups. The US treatment also enhanced bone growth of the sham-treated contralateral fracture site. These results suggest that US treatment at 0.5, 1.0, 1.5 or 2.0 MHz can enhance fracture healing in a rabbit model. Furthermore, the effects of US on fracture healing at present parameters might not be confined locally.
KW - Fractured bone healing
KW - New bone growth
KW - Torsional stiffness
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=80052894697&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052894697&partnerID=8YFLogxK
U2 - 10.1016/j.ultrasmedbio.2011.06.014
DO - 10.1016/j.ultrasmedbio.2011.06.014
M3 - Article
C2 - 21821345
AN - SCOPUS:80052894697
SN - 0301-5629
VL - 37
SP - 1635
EP - 1643
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 10
ER -