Effects of the O2' Hydroxyl Group on Z-DNA Conformation: Structure of Z-RNA and (araC)-[Z-DNA]

Mai kun Teng, Yen Chywan Liaw, Gijs A. van der Marel, Jacques H. van Boom, Andrew H.J. Wang

研究成果: 雜誌貢獻文章同行評審

39 引文 斯高帕斯(Scopus)

摘要

The left-handed Z structures of two hexamers [d(CG)r(CG)d(CG) and d(CG)(araC)d(GCG)] containing ribose and arabinose residues have been solved by X-ray diffraction analysis at 1.5-Å resolution. Their conformations closely resemble that of the canonical Z-DNA. The O2' hydroxyl groups of both rC and araC residues form intramolecular hydrogen bonds with N2 of the 5' guanine residue and replace the bridging water molecules in the deep groove of Z-DNA, which stabilize the guanine in the syn conformation. The araC residue can be incorporated into the Z structure readily and facilitates B to Z transition, as supported by UV absorption spectroscopic studies. In contrast, in Z-RNA the ribose of the cytidine residue is twisted in order to form the respective hydrogen bond. The potential biological roles of the modified Z-DNA containing anticancer nucleoside araC and of Z-RNA are discussed.

原文英語
頁(從 - 到)4923-4928
頁數6
期刊Biochemistry
28
發行號12
DOIs
出版狀態已發佈 - 6月 1 1989
對外發佈

ASJC Scopus subject areas

  • 生物化學

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