摘要
Study Design:Experimental, controlled, animal study.Objectives:To assess the effects of vitamins C and E (VCE) treatment on oxidative stress and programmed cell deaths after rat spinal cord injury (SCI), as well as functional recovery.Setting:Taiwan.Methods:Fifty-four Sprague-Dawley rats were used for the experimental procedure. In the sham group, laminectomy at T10 was performed, followed by impactor contusion of the spinal cord. In the control group, only a laminectomy was performed without contusion. Oxidative stress status was assessed by measuring the spinal cord tissue content of superoxide dismutase (SOD) and gluthatione peroxidase (GSH-Px) activities. We also evaluated the effects of combined VCE treatment using western blot to analyze expression of cleaved caspase-3 and microtubule-associated protein light chain 3 (LC3), and the Basso, Beattie and Bresnahan (BBB) scale to evaluate functional outcomes.Results:Combined treatment of VCE significantly counteracted the effects of spinal cord contusion on oxidative stress represented by activities of SOD and GSH-Px (P
原文 | 英語 |
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頁(從 - 到) | 24-28 |
頁數 | 5 |
期刊 | Spinal Cord |
卷 | 52 |
發行號 | 1 |
DOIs | |
出版狀態 | 已發佈 - 1月 2014 |
ASJC Scopus subject areas
- 神經病學(臨床)
- 神經內科