Effects of [ 123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague-Dawley rats

K. W. Chang, M. C. Lin, S. Y. Lee, H. Y. Chen, C. C. Chen, Y. K. Fu

研究成果: 雜誌貢獻文章同行評審

摘要

Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [ 123I]ADAM ([ 123I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [ 123I]ADAM (18.5MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [ 123I]ADAM was not toxic in an animal pregnancy model.
原文英語
頁(從 - 到)2646-2651
頁數6
期刊Applied Radiation and Isotopes
70
發行號11
DOIs
出版狀態已發佈 - 十一月 1 2012
對外發佈Yes

ASJC Scopus subject areas

  • Radiation

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