Effects of steroids on renal nad+-dependent 15-hydroxy-prostaglandin dehydrogenase activity in ovariectomized rats

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)


It has been suggested that the circulating prostacyclin in primarily inactivated by renal NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Changes in the renal enzyme activity in response to hormones were studied. The renal 15-hydroxyprostaglandin dehydrogenase activity in female rats was lower than that in male rats, and was significantly increased by ovariectomy. The effect of sex steroids on the renal enzyme activity was then studied in ovariectomized rats. Estradiol administration induced a significant decrease in the renal enzyme activity, while testosterone did not show any significant effect. Kinetic parameters for the renal enzyme from control and estradiol-treated groups were compared. An identical apparent Km for prostaglandin E2 was obtained for the enzyme from both groups. Vmax in the treated group was progressively decreased. The enzyme from both groups decayed at the same rate. The results indicated that estradiol might be the major endogenous sex steroid regulating the renal NAD+-dependent 15-hydroxyprostaglandin dehydrogenase activity, and the inhibitory effect of estradiol on the renal enzyme might be due to the inhibition of the enzyme biosynthesis.

頁(從 - 到)25-32
期刊Prostaglandins, Leukotrienes and Medicine
出版狀態已發佈 - 九月 1987

ASJC Scopus subject areas

  • 生物化學
  • 生理學
  • 內分泌


深入研究「Effects of steroids on renal nad<sup>+</sup>-dependent 15-hydroxy-prostaglandin dehydrogenase activity in ovariectomized rats」主題。共同形成了獨特的指紋。