Effects of soy protein hydrolysate on blood pressure and angiotensin-converting enzyme activity in rats with chronic renal failure

Hsin Y. Yang, Jiun Rong Chen, Le Shin Chang

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

We investigated the effects of soy protein and soy protein hydrolysate on blood pressure control, angiotensin-converting enzyme (ACE) activity, and renal function in a rat chronic renal failure model. Rats that had undergone a 5/6 nephrOctomy were separated into three groups and fed different experimental diets for 14 weeks. At the end of the study, rats that fed a diet containing soy protein as the protein source had better blood pressure control and renal function, as well as lower circulating ACE activity and renal tumor-necrosis factor-α (TNF-α) concentration than rats fed a caseln protein diet. Soy protein hydrolysate was shown to be as effective as say protein In preventing the elevation of blood pressure, the progression of renal failure, and decreases in kidney TNP-α level, plasma ACE activity, and insulin concentration, In conclusion, the beneficial effects of consuming soy protein on blood pressure and renal function may be mediated mostly by its pepsin-digested hydrolyeate through its ACE inhibitory activity.

原文英語
頁(從 - 到)957-963
頁數7
期刊Hypertension Research
31
發行號5
DOIs
出版狀態已發佈 - 5月 2008

ASJC Scopus subject areas

  • 內科學

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