摘要
After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 313-317 |
| 頁數 | 5 |
| 期刊 | Toxicology Letters |
| 卷 | 25 |
| 發行號 | 3 |
| DOIs | |
| 出版狀態 | 已發佈 - 1985 |
指紋
ASJC Scopus subject areas
- Toxicology
引用此文
Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats. / Noda, A.; Sendo, T.; Ohno, K.; Goto, S.; Noda, H.; Hsu, K. Y.
於: Toxicology Letters, 卷 25, 編號 3, 1985, p. 313-317.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats
AU - Noda, A.
AU - Sendo, T.
AU - Ohno, K.
AU - Goto, S.
AU - Noda, H.
AU - Hsu, K. Y.
PY - 1985
Y1 - 1985
N2 - After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.
AB - After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.
KW - Hydrazine
KW - liver
KW - mass fragmentography
KW - plasma
KW - urine
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UR - http://www.scopus.com/inward/citedby.url?scp=0021854059&partnerID=8YFLogxK
U2 - 10.1016/0378-4274(85)90213-9
DO - 10.1016/0378-4274(85)90213-9
M3 - Article
C2 - 4012807
AN - SCOPUS:0021854059
VL - 25
SP - 313
EP - 317
JO - Toxicology Letters
JF - Toxicology Letters
SN - 0378-4274
IS - 3
ER -