Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats

A. Noda, T. Sendo, K. Ohno, S. Goto, H. Noda, K. Y. Hsu

研究成果: 雜誌貢獻文章

12 引文 (Scopus)

摘要

After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.

原文英語
頁(從 - 到)313-317
頁數5
期刊Toxicology Letters
25
發行號3
DOIs
出版狀態已發佈 - 1985

指紋

hydrazine
Isoniazid
Rifampin
Phenobarbital
Rats
Mutagens
Metabolites
Carcinogens
Liver
Toxicology
Spectrometry
Wistar Rats
Spectrum Analysis
Gases
Plasmas
Control Groups

ASJC Scopus subject areas

  • Toxicology

引用此文

Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats. / Noda, A.; Sendo, T.; Ohno, K.; Goto, S.; Noda, H.; Hsu, K. Y.

於: Toxicology Letters, 卷 25, 編號 3, 1985, p. 313-317.

研究成果: 雜誌貢獻文章

Noda, A. ; Sendo, T. ; Ohno, K. ; Goto, S. ; Noda, H. ; Hsu, K. Y. / Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats. 於: Toxicology Letters. 1985 ; 卷 25, 編號 3. 頁 313-317.
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abstract = "After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.",
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T1 - Effects of rifampicin and phenobarbital on the fate of isoniazid and hydrazine in vivo in rats

AU - Noda, A.

AU - Sendo, T.

AU - Ohno, K.

AU - Goto, S.

AU - Noda, H.

AU - Hsu, K. Y.

PY - 1985

Y1 - 1985

N2 - After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.

AB - After the intraperitoneal (i.p.) administration of isoniazid (INH) to male Wistar rats, the liver and plasma levels of hydrazine (Hz) and acetylhydrazine (AcHz), which are hazardous metabolites of INH and well known as mutagens, carcinogens and hepatotoxins, were determined by gas chromatographymass spectrometry (GC-MS). The levels of Hz in rifampicin (RMP)- or phenobarbital (PB)-pretreated groups were lower than those in the control group, while the amount of AcHz was scarcely altered. In each of the pretreated groups a pronounced increase in the oxidative elimination rate of Hz was observed. These results are of important toxicological significance in INH therapy with RMP, since an active intermediate of Hz seems to be a hepatotoxin.

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KW - mass fragmentography

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KW - urine

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