Effects of rapid atrial pacing on the arrhythmogenic activity of single cardiomyocytes from pulmonary veins: Implication in initiation of atrial fibrillation

Yi J. Chen, Shih A. Chen, Yao Chang Chen, Hung I. Yeh, Paul Chan, Mau Song Chang, Cheng I. Lin

研究成果: 雜誌貢獻文章

233 引文 斯高帕斯(Scopus)

摘要

Background - Pulmonary veins (PVs) are important sources of paroxysmal atrial fibrillation. Long-term rapid atrial pacing (RAP) changes atrial electrophysiology and facilitates the maintenance of atrial fibrillation. It is not clear whether RAP alters the arrhythmogenic activity of PVs. The purpose of this study was to isolate single PV cardiomyocytes from control and RAP dogs and evaluate their electrophysiological characteristics. Methods and Results - The action potential and ionic currents were investigated in PV cardiomyocytes from control and long-term (6 to 8 weeks) RAP (780 bpm) dogs by use of the whole-cell clamp technique. Dissociation of PVs yielded rod-shaped single cardiomyocytes without (n=91, 60%) or with (n=60, 40%) pacemaker activity. Compared with the control group, the RAP dog PV cardiomyocytes had faster beating rates (0.86±0.28 versus 0.45±0.07 Hz, P

原文英語
頁(從 - 到)2849-2854
頁數6
期刊Circulation
104
發行號23
出版狀態已發佈 - 十二月 4 2001
對外發佈Yes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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