摘要
Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 9274-9279 |
| 頁數 | 6 |
| 期刊 | Journal of Agricultural and Food Chemistry |
| 卷 | 57 |
| 發行號 | 19 |
| DOIs | |
| 出版狀態 | 已發佈 - 2009 |
指紋
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Chemistry(all)
引用此文
Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses. / Liu, Yen Wenn; Liu, J. U Chi; Huang, Chun Yao; Wang, Chung Kwe; Shang, Huey Fang; Hou, Wen Chi.
於: Journal of Agricultural and Food Chemistry, 卷 57, 編號 19, 2009, p. 9274-9279.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses
AU - Liu, Yen Wenn
AU - Liu, J. U Chi
AU - Huang, Chun Yao
AU - Wang, Chung Kwe
AU - Shang, Huey Fang
AU - Hou, Wen Chi
PY - 2009
Y1 - 2009
N2 - Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p
AB - Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p
KW - Dioscorin
KW - Immunomodulatory
KW - Mucosal
KW - Yam
UR - http://www.scopus.com/inward/record.url?scp=70349921001&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349921001&partnerID=8YFLogxK
U2 - 10.1021/jf902245k
DO - 10.1021/jf902245k
M3 - Article
C2 - 19743857
AN - SCOPUS:70349921001
VL - 57
SP - 9274
EP - 9279
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
SN - 0021-8561
IS - 19
ER -