Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses

Yen Wenn Liu, J. U Chi Liu, Chun Yao Huang, Chung Kwe Wang, Huey Fang Shang, Wen Chi Hou

研究成果: 雜誌貢獻文章

21 引文 (Scopus)

摘要

Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p

原文英語
頁(從 - 到)9274-9279
頁數6
期刊Journal of Agricultural and Food Chemistry
57
發行號19
DOIs
出版狀態已發佈 - 2009

指紋

Dioscorea
Cytophagocytosis
yams
natural killer cells
storage proteins
splenocytes
phagocytosis
Natural Killer Cells
oral administration
Oral Administration
mouth
tubers
Cells
immune response
Peyer's Patches
Peyer's patches
Lymphocytes
Macrophages
Lymphocyte Subsets
mice

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Chemistry(all)

引用此文

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title = "Effects of oral administration of Yam tuber storage protein, dioscorin, to BALB/c mice for 21-days on immune responses",
abstract = "Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p",
keywords = "Dioscorin, Immunomodulatory, Mucosal, Yam",
author = "Liu, {Yen Wenn} and Liu, {J. U Chi} and Huang, {Chun Yao} and Wang, {Chung Kwe} and Shang, {Huey Fang} and Hou, {Wen Chi}",
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AU - Liu, Yen Wenn

AU - Liu, J. U Chi

AU - Huang, Chun Yao

AU - Wang, Chung Kwe

AU - Shang, Huey Fang

AU - Hou, Wen Chi

PY - 2009

Y1 - 2009

N2 - Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p

AB - Dioscorin, the tuber storage protein of yam, was reported to have immunomodulatory activity in RAW264.7 murine macrophage cell lines (Food and Chemical Toxicology, 2007, 45, 2312-2318). However, the immunomodulatory function of dioscorin after being ingested was not elucidated in vivo. Hence, BALB/c mice were given oral dioscorin (2.5 and 20 mg/kg/day) once a day for 21-days. Lymphocyte subpopulation changes in the peripheral blood and splenocytes, stimulation in phagocytosis of the polymorphonuclear cell (PMN) and monocytes, the natural killer (NK) cell cytotoxicity, the splenocyte proliferation, and cytokine secretions in the presence of PHA were determined. The number changes of Peyer's patches and secreted IgA (slgA) in the feces were determined. Oral dioscorin for 21-days increased the subpopulation in natural killer cells (CD49+) and/or B cells (CD19+), elevated the phagocytosis of PMN (p

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KW - Immunomodulatory

KW - Mucosal

KW - Yam

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