Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition

Sung Ling Yeh, Ken Yu Chang, Po Chao Huang, Wei Jao Chen

研究成果: 雜誌貢獻文章

57 引文 (Scopus)

摘要

The effect of total parenteral nutrition (TPN) enriched with n-3 or n-6 fatty acids on the concentration of plasma eicosanoids was evaluated in rats. Rats were divided into three groups: the control group (n = 6) was fed a chow diet and infused with saline only. Two experimental groups (n = 11, 13) received TPN solutions at an energy level of 30 kcal/100 g body weight with 40% energy provided as fat. The experimental groups were maintained on TPN for a period of 7 d. The basal TPN solutions were isonitrogenous and identical in nutrient composition except for differences in lipid source. One experimental group received a safflower oil emulsion, whereas the other group received a fish oil emulsion. At the end of the experimental period, plasma 6-keto prostaglandin F(1α), thromboxane B2, bleeding time, lipid peroxidation products, and antioxidant enzymes of liver were analyzed. The results demonstrated that the fish oil group had lower 6-keto prostaglandin F(1α) concentration than the safflower oil group. Also, plasma thromboxane B2 was the lowest in the fish oil group among the three groups. There was no difference in bleeding time among the groups. With regard to liver lipid peroxidation products, malondialdehyde concentration was not higher in the fish oil group, whereas superoxide dismutase and glutathione peroxidase activities were lower in the fish oil group compared with the control and safflower oil groups. The results suggest that TPN prepared with fish oil fat emulsion causes less accumulation of lipid peroxidation products in the liver of rats, and may be beneficial in preventing platelet aggregation.

原文英語
頁(從 - 到)32-36
頁數5
期刊Nutrition
13
發行號1
DOIs
出版狀態已發佈 - 一月 1997

指紋

Eicosanoids
Fish Oils
Total Parenteral Nutrition
Fatty Acids
Antioxidants
Safflower Oil
Liver
Enzymes
Emulsions
Parenteral Nutrition Solutions
Lipid Peroxidation
Thromboxane B2
Bleeding Time
Prostaglandins F
Fats
Glutathione Peroxidase
Malondialdehyde
Platelet Aggregation
Superoxide Dismutase
Body Weight

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Surgery
  • Medicine (miscellaneous)

引用此文

Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. / Yeh, Sung Ling; Chang, Ken Yu; Huang, Po Chao; Chen, Wei Jao.

於: Nutrition, 卷 13, 編號 1, 01.1997, p. 32-36.

研究成果: 雜誌貢獻文章

Yeh, Sung Ling ; Chang, Ken Yu ; Huang, Po Chao ; Chen, Wei Jao. / Effects of n-3 and n-6 fatty acids on plasma eicosanoids and liver antioxidant enzymes in rats receiving total parenteral nutrition. 於: Nutrition. 1997 ; 卷 13, 編號 1. 頁 32-36.
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abstract = "The effect of total parenteral nutrition (TPN) enriched with n-3 or n-6 fatty acids on the concentration of plasma eicosanoids was evaluated in rats. Rats were divided into three groups: the control group (n = 6) was fed a chow diet and infused with saline only. Two experimental groups (n = 11, 13) received TPN solutions at an energy level of 30 kcal/100 g body weight with 40{\%} energy provided as fat. The experimental groups were maintained on TPN for a period of 7 d. The basal TPN solutions were isonitrogenous and identical in nutrient composition except for differences in lipid source. One experimental group received a safflower oil emulsion, whereas the other group received a fish oil emulsion. At the end of the experimental period, plasma 6-keto prostaglandin F(1α), thromboxane B2, bleeding time, lipid peroxidation products, and antioxidant enzymes of liver were analyzed. The results demonstrated that the fish oil group had lower 6-keto prostaglandin F(1α) concentration than the safflower oil group. Also, plasma thromboxane B2 was the lowest in the fish oil group among the three groups. There was no difference in bleeding time among the groups. With regard to liver lipid peroxidation products, malondialdehyde concentration was not higher in the fish oil group, whereas superoxide dismutase and glutathione peroxidase activities were lower in the fish oil group compared with the control and safflower oil groups. The results suggest that TPN prepared with fish oil fat emulsion causes less accumulation of lipid peroxidation products in the liver of rats, and may be beneficial in preventing platelet aggregation.",
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