TY - JOUR
T1 - Effects of Muscle Strength Training on Muscle Mass Gain and Hypertrophy in Older Adults With Osteoarthritis
T2 - A Systematic Review and Meta-Analysis
AU - Liao, Chun De
AU - Chen, Hung Chou
AU - Kuo, Yu Chi
AU - Tsauo, Jau Yih
AU - Huang, Shih Wei
AU - Liou, Tsan Hon
N1 - Funding Information:
The authors thank Wallace Academic Editing for editing the manuscript.
Publisher Copyright:
© 2020, American College of Rheumatology
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Objective: To investigate the effect of muscle strength exercise training (MSET) on lean mass (LM) gain and muscle hypertrophy in older patients with lower extremity osteoarthritis (OA). Methods: A comprehensive search of online databases was performed on April 20, 2019. Randomized controlled trials (RCTs) that reported the effects of MSET on LM, muscle thickness, and cross-sectional area (CSA) in older patients with OA were identified. A risk of bias assessment and meta-analysis were performed for the included RCTs. Results: We included 19 RCTs with a median Physiotherapy Evidence Database score of 6 of 10 (range 3–7). In total, data from 1,195 patients (65% women, 85% with knee OA) with a mean age of 62.1 years (range 40–86 years) were analyzed. MSET resulted in significantly higher LM gain (standardized mean difference [SMD] 0.49 [95% confidence interval (95% CI) 0.28, 0.71], P < 0.00001) than did the nonexercise controls. Meta-analysis results revealed significantly positive effects of MSET on muscle thickness (SMD 0.82 [95% CI 0.20, 1.43], P = 0.009) and CSA (SMD 0.80 [95% CI 0.25, 1.35], P = 0.004) compared with nonexercise controls. No significant effects in favor of MSET were observed for any muscle outcome compared with exercise controls. Five RCTs reported nonsevere adverse events in response to MSET, whereas no RCTs reported severe events. Conclusion: MSET is effective in increasing LM and muscle size in older adults with OA. Clinicians should incorporate MSET into their management of patients at risk of low muscle mass to maximize health status, particularly for older individuals with OA.
AB - Objective: To investigate the effect of muscle strength exercise training (MSET) on lean mass (LM) gain and muscle hypertrophy in older patients with lower extremity osteoarthritis (OA). Methods: A comprehensive search of online databases was performed on April 20, 2019. Randomized controlled trials (RCTs) that reported the effects of MSET on LM, muscle thickness, and cross-sectional area (CSA) in older patients with OA were identified. A risk of bias assessment and meta-analysis were performed for the included RCTs. Results: We included 19 RCTs with a median Physiotherapy Evidence Database score of 6 of 10 (range 3–7). In total, data from 1,195 patients (65% women, 85% with knee OA) with a mean age of 62.1 years (range 40–86 years) were analyzed. MSET resulted in significantly higher LM gain (standardized mean difference [SMD] 0.49 [95% confidence interval (95% CI) 0.28, 0.71], P < 0.00001) than did the nonexercise controls. Meta-analysis results revealed significantly positive effects of MSET on muscle thickness (SMD 0.82 [95% CI 0.20, 1.43], P = 0.009) and CSA (SMD 0.80 [95% CI 0.25, 1.35], P = 0.004) compared with nonexercise controls. No significant effects in favor of MSET were observed for any muscle outcome compared with exercise controls. Five RCTs reported nonsevere adverse events in response to MSET, whereas no RCTs reported severe events. Conclusion: MSET is effective in increasing LM and muscle size in older adults with OA. Clinicians should incorporate MSET into their management of patients at risk of low muscle mass to maximize health status, particularly for older individuals with OA.
UR - http://www.scopus.com/inward/record.url?scp=85096777012&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85096777012&partnerID=8YFLogxK
U2 - 10.1002/acr.24097
DO - 10.1002/acr.24097
M3 - Article
C2 - 31628720
AN - SCOPUS:85096777012
VL - 72
SP - 1703
EP - 1718
JO - Arthritis care and research : the official journal of the Arthritis Health Professions Association
JF - Arthritis care and research : the official journal of the Arthritis Health Professions Association
SN - 2326-5191
IS - 12
ER -