Effects of microvascular permeability changes on contrast-enhanced t1 and pharmacokinetic mr imagings after ischemia

Hua Shan Liu, Hsiao Wen Chung, Ming Chung Chou, Michelle Liou, Chao Ying Wang, Hung Wen Kao, Shih Wei Chiang, Chun Jung Juan, Guo Shu Huang, Cheng Yu Chen

研究成果: 雜誌貢獻文章

16 引文 斯高帕斯(Scopus)

摘要

BACKGROUND AND PURPOSE - : Brain enhancement on contrast-enhanced T1-weighted imaging (CET1-WI) after ischemic stroke is generally accepted as an indicator of the blood-brain barrier disruption. However, this phenomenon usually starts to become visible at the subacute phase. The purpose of this study was to evaluate the time-course profiles of K, cerebral blood volume (vp), and CET1-WI with early detection of blood-brain barrier changes on K maps and their role for prediction of subsequent hemorrhagic transformation in acute middle cerebral arterial infarct. METHODS - : Twenty-six patients with acute middle cerebral arterial stroke and early spontaneous reperfusion, whose MR images were obtained at predetermined stroke stages, were included. T2*-based MR perfusion-weighted images were acquired using the first-pass pharmacokinetic model to derive K and vp. Parenchymal enhancement observed on maps of K, vp, and CET1-WI at each stage was compared. Association among these measurements and hemorrhagic transformation was analyzed. RESULTS - : K map showed significantly higher parenchymal enhancement in ischemic parenchyma as compared with that of vp map and CET1-WI at early stroke stages (P
原文英語
頁(從 - 到)1872-1877
頁數6
期刊Stroke
44
發行號7
DOIs
出版狀態已發佈 - 七月 2013

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

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    Liu, H. S., Chung, H. W., Chou, M. C., Liou, M., Wang, C. Y., Kao, H. W., Chiang, S. W., Juan, C. J., Huang, G. S., & Chen, C. Y. (2013). Effects of microvascular permeability changes on contrast-enhanced t1 and pharmacokinetic mr imagings after ischemia. Stroke, 44(7), 1872-1877. https://doi.org/10.1161/STROKEAHA.113.001558