Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus

Yi Chun Kuan, Kuang Wei Huang, Cheng Li Lin, Chaur Jong Hu, Chia Hung Kao

研究成果: 雜誌貢獻文章

49 引文 斯高帕斯(Scopus)

摘要

Epidemiological evidence reveals that patients with type 2 diabetes mellitus (T2DM) have an increased risk of neurodegenerative diseases (NDs), including dementia and Parkinson's disease (PD). The effects of metformin exposure on dementia and PD risk in patients with T2DM are unknown. We evaluated the effects of metformin exposure on the risk of dementia and PD in patients with T2DM. We performed a cohort study by using Taiwan's National Health Insurance Research Database. We recruited 4651 patients in the metformin cohort and a comparable number of nonmetformin controls by using propensity score matching. Multivariate Cox proportional hazards regression was used to estimate the effects of metformin on the risk of dementia and PD after adjustment for several confounding factors. During the 12-year follow-up, the metformin cohort exhibited a higher risk of PD than the nonmetformin cohort (hazard ratio [HR]: 2.27, 95% confidence interval [CI] = 1.68–3.07). The metformin cohort had an increased risk of all-cause dementia (HR: 1.66, 95% CI = 1.35–2.04). Moreover, metformin exposure increased the risk of Alzheimer's disease (HR: 2.13, 95% CI = 1.20–3.79) and vascular dementia (HR: 2.30, 95% CI = 1.25–4.22). The effects of exposure duration and dosage on dementia and PD occurrence were also observed. Long-term metformin exposure in patients with T2DM may lead to the development of NDs, including dementia and PD. Additional large-scale, prospective controlled trials are required to confirm the observed association in patients with T2DM.
原文英語
頁(從 - 到)77-83
頁數7
期刊Progress in Neuro-Psychopharmacology and Biological Psychiatry
79
DOIs
出版狀態已發佈 - 十月 3 2017

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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