Effects of Maternal Undernutrition on Glomerular Ultrastructure in Rat Offspring

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Background: Intrauterine growth restriction (IUGR) can reduce glomerular number and increase blood pressure in rats. The aim of this study was to assess the effects of maternal undernutrition during late gestation on glomerular ultrastructure in adult rat offspring. Methods: Timed pregnant Sprague-Dawley rats were used. Control dams received regular food throughout pregnancy, while experimental dams received 50% of control food intake from days 15-21 of gestation. Glomerular ultrastructure was quantified in male offspring at 16 weeks of age. Results: The ultrastructure of the filtration apparatus in the IUGR rat glomeruli was indistinguishable from that in the control rat glomeruli. The relative volumes of the glomerulus occupied by podocytes, capillaries, and mesangium, and the thickness of the glomerular basement membrane (GBM), and width of the filtration slit were comparable between control and IUGR rats. Conclusion: These results indicate that glomerular ultrastructure is not affected by maternal undernutrition and suggest that altered glomerular ultrastructure is not a contributory factor to the pathogenesis of hypertension following maternal undernutrition.
原文英語
頁(從 - 到)50-53
頁數4
期刊Pediatrics and Neonatology
50
發行號2
DOIs
出版狀態已發佈 - 四月 2009

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

指紋 深入研究「Effects of Maternal Undernutrition on Glomerular Ultrastructure in Rat Offspring」主題。共同形成了獨特的指紋。

引用此