Effects of maternal nicotine exposure on lung surfactant system in rats

Chung Ming Chen, Leng-Fang Wang, Tsu Fuh Yeh

研究成果: 雜誌貢獻文章

17 引文 (Scopus)

摘要

Maternal smoking during pregnancy may impair pulmonary function in infants and children, but the exact mechanisms underlying these changes remain to be determined. Timed pregnant Sprague-Dawley rats were injected subcutaneously with nicotine at a dose of 2 mg/kg/ day from days 3-21 of gestation. A control group was injected with saline. Nicotine-treated dams had lower body weights than control dams from gestational days 5-21, and the values reached statistical significance on gestational days 17, 20, and 21. Total lung saturated phosphatidylcholine contents tended to be lower in nicotine-exposed rats than in control rats from postnatal day 21, and the values reached statistical significance on postnatal days 35 and 42. Maternal nicotine exposure significantly increased surfactant protein (SP)-A, SP-B, SP-C, and SP-D mRNA expression on postnatal day 7, and decreased SP-A, SP-B, SP-C, and SP-D mRNA expression on postnatal day 14. In conclusion, maternal nicotine exposure during pregnancy reduces lung surfactant lipids and produces variable changes in surfactant protein gene expression during the late postnatal period. As good surface activity of pulmonary surfactant is essential for normal lung function, these results suggest that derangement of the pulmonary surfactant system may be important in the pathogenesis of impaired pulmonary function in children exposed in utero to nicotine.
原文英語
頁(從 - 到)97-102
頁數6
期刊Pediatric Pulmonology
39
發行號2
DOIs
出版狀態已發佈 - 二月 2005

指紋

Maternal Exposure
Nicotine
Surface-Active Agents
Lung
Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactants
Protein C
Pregnancy
Messenger RNA
Phosphatidylcholines
Sprague Dawley Rats
Smoking
Body Weight
Mothers
Lipids
Gene Expression
Control Groups
Proteins

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

引用此文

Effects of maternal nicotine exposure on lung surfactant system in rats. / Chen, Chung Ming; Wang, Leng-Fang; Yeh, Tsu Fuh.

於: Pediatric Pulmonology, 卷 39, 編號 2, 02.2005, p. 97-102.

研究成果: 雜誌貢獻文章

Chen, Chung Ming ; Wang, Leng-Fang ; Yeh, Tsu Fuh. / Effects of maternal nicotine exposure on lung surfactant system in rats. 於: Pediatric Pulmonology. 2005 ; 卷 39, 編號 2. 頁 97-102.
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