Effects of lysosomal deposition on the friction coefficient of hydrogel contact lenses

Chen Ying Su, Lung Kun Yeh, Chi Chun Lai, Kuan Yi Li, Ching Li Tseng, Hsu Wei Fang

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

When a contact lens is in contact with the eyelid and the cornea, tear proteins start to be accumulated on the lens and may subsequently undergo conformational changes. Protein adsorption or conformational changes on the lens may lead to discomfort, red eye, or even inflammatory reactions. Although measuring the friction coefficient of contact lens has been linked to comfort degree in vivo, there is not much research about the effects of tear protein deposition on the friction coefficient of the contact lens. Therefore, we investigated the friction coefficient of three distinct materials of contact lenses in two different lysosomal concentrations. We also studied lysozyme deposition on the lens without the influence of friction. The results demonstrated that although the amount of lysozyme deposition was high on all the materials we tested, it was not corresponded to higher friction coefficient. In addition, we investigated the effect of the contact lens care solution we developed on friction coefficient and lysozyme deposition of three different materials of contact lenses. The results showed that the care solution could reduce the increased friction coefficient caused by high lysosomal concentration. Therefore, we proposed a potential mechanism of why lysosomal deposition may result in high friction coefficient for certain types of hydrogel contact lenses.

原文英語
期刊Contact Lens and Anterior Eye
DOIs
出版狀態接受/付印 - 一月 1 2019

指紋

Friction
Hydrogel
Contact Lenses
Muramidase
Lenses
Contact Lens Solutions
Eyelids
Cornea
Adsorption
Research

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry

引用此文

Effects of lysosomal deposition on the friction coefficient of hydrogel contact lenses. / Su, Chen Ying; Yeh, Lung Kun; Lai, Chi Chun; Li, Kuan Yi; Tseng, Ching Li; Fang, Hsu Wei.

於: Contact Lens and Anterior Eye, 01.01.2019.

研究成果: 雜誌貢獻文章

Su, Chen Ying ; Yeh, Lung Kun ; Lai, Chi Chun ; Li, Kuan Yi ; Tseng, Ching Li ; Fang, Hsu Wei. / Effects of lysosomal deposition on the friction coefficient of hydrogel contact lenses. 於: Contact Lens and Anterior Eye. 2019.
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abstract = "When a contact lens is in contact with the eyelid and the cornea, tear proteins start to be accumulated on the lens and may subsequently undergo conformational changes. Protein adsorption or conformational changes on the lens may lead to discomfort, red eye, or even inflammatory reactions. Although measuring the friction coefficient of contact lens has been linked to comfort degree in vivo, there is not much research about the effects of tear protein deposition on the friction coefficient of the contact lens. Therefore, we investigated the friction coefficient of three distinct materials of contact lenses in two different lysosomal concentrations. We also studied lysozyme deposition on the lens without the influence of friction. The results demonstrated that although the amount of lysozyme deposition was high on all the materials we tested, it was not corresponded to higher friction coefficient. In addition, we investigated the effect of the contact lens care solution we developed on friction coefficient and lysozyme deposition of three different materials of contact lenses. The results showed that the care solution could reduce the increased friction coefficient caused by high lysosomal concentration. Therefore, we proposed a potential mechanism of why lysosomal deposition may result in high friction coefficient for certain types of hydrogel contact lenses.",
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AU - Tseng, Ching Li

AU - Fang, Hsu Wei

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