Effects of linearly polarized near-infrared irradiation near the stellate ganglion region on pain and heart rate variability in patients with neuropathic pain

Chun De Liao, Chi Lun Rau, Tsan Hon Liou, Jau Yih Tsauo, Li Fong Lin

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Background. Neuropathic pain associated with sympathetic overactivity can be effectively relieved by light irradiating the region near stellate ganglion (SGI), applied as an alternative to a conventional sympathetic blockade. The clinical effect of SGI on heart rate variability (HRV) and its association with pain outcomes require investigation. Objective. This study attempted to identify the effects of SGI on pain outcomes and HRV indices and to determine the association between pain and HRV outcomes. Design. A prospective double-blind, randomized study. Setting. An outpatient pain medicine clinic. Subjects and Methods. A total of 44 patients were enrolled and randomized into the experimental group (n 5 22) and control group (n 5 22). The experimental group received 12 sessions (twice weekly) of standard SGI, whereas the control group received the same protocol with sham irradiation. Pain and HRV were measured before and after each irradiation session. All outcome measures used in the first- and secondhalf treatment courses were analyzed. Results. Pain and HRV outcome measures of the experimental group significantly improved after SGI when compared with the control group in both courses. Considering time and frequency domains, the changes in HRV in the second-half treatment course exceeded those in the first-half treatment course. Pain was significantly associated with postirradiated HRV indices (P < 0.001). Conclusions. Twelve sessions of SGI exerted timedependent positive effects on pain and sympathovagal imbalance. HRV outcomes, including time and frequency domains, were an independent indicator of the clinical efficiency of SGI for treating pain in patients with neuropathic pain.

原文英語
頁(從 - 到)488-503
頁數16
期刊Pain Medicine (United States)
18
發行號3
DOIs
出版狀態已發佈 - 2017

指紋

Stellate Ganglion
Neuralgia
Heart Rate
Pain
Control Groups
Outcome Assessment (Health Care)
Pain Clinics
Double-Blind Method
Outpatients
Therapeutics
Medicine
Light

ASJC Scopus subject areas

  • Clinical Neurology

引用此文

@article{58a6aa5763fb41fb8be4010e570f2ebb,
title = "Effects of linearly polarized near-infrared irradiation near the stellate ganglion region on pain and heart rate variability in patients with neuropathic pain",
abstract = "Background. Neuropathic pain associated with sympathetic overactivity can be effectively relieved by light irradiating the region near stellate ganglion (SGI), applied as an alternative to a conventional sympathetic blockade. The clinical effect of SGI on heart rate variability (HRV) and its association with pain outcomes require investigation. Objective. This study attempted to identify the effects of SGI on pain outcomes and HRV indices and to determine the association between pain and HRV outcomes. Design. A prospective double-blind, randomized study. Setting. An outpatient pain medicine clinic. Subjects and Methods. A total of 44 patients were enrolled and randomized into the experimental group (n 5 22) and control group (n 5 22). The experimental group received 12 sessions (twice weekly) of standard SGI, whereas the control group received the same protocol with sham irradiation. Pain and HRV were measured before and after each irradiation session. All outcome measures used in the first- and secondhalf treatment courses were analyzed. Results. Pain and HRV outcome measures of the experimental group significantly improved after SGI when compared with the control group in both courses. Considering time and frequency domains, the changes in HRV in the second-half treatment course exceeded those in the first-half treatment course. Pain was significantly associated with postirradiated HRV indices (P < 0.001). Conclusions. Twelve sessions of SGI exerted timedependent positive effects on pain and sympathovagal imbalance. HRV outcomes, including time and frequency domains, were an independent indicator of the clinical efficiency of SGI for treating pain in patients with neuropathic pain.",
keywords = "Autonomic Dysfunction, Heart Rate Variability, Linear Polarized Near-Infrared Irradiation, Neuropathic Pain, Stellate Ganglion",
author = "Liao, {Chun De} and Rau, {Chi Lun} and Liou, {Tsan Hon} and Tsauo, {Jau Yih} and Lin, {Li Fong}",
year = "2017",
doi = "10.1093/pm/pnw145",
language = "English",
volume = "18",
pages = "488--503",
journal = "Pain Medicine",
issn = "1526-2375",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Effects of linearly polarized near-infrared irradiation near the stellate ganglion region on pain and heart rate variability in patients with neuropathic pain

AU - Liao, Chun De

AU - Rau, Chi Lun

AU - Liou, Tsan Hon

AU - Tsauo, Jau Yih

AU - Lin, Li Fong

PY - 2017

Y1 - 2017

N2 - Background. Neuropathic pain associated with sympathetic overactivity can be effectively relieved by light irradiating the region near stellate ganglion (SGI), applied as an alternative to a conventional sympathetic blockade. The clinical effect of SGI on heart rate variability (HRV) and its association with pain outcomes require investigation. Objective. This study attempted to identify the effects of SGI on pain outcomes and HRV indices and to determine the association between pain and HRV outcomes. Design. A prospective double-blind, randomized study. Setting. An outpatient pain medicine clinic. Subjects and Methods. A total of 44 patients were enrolled and randomized into the experimental group (n 5 22) and control group (n 5 22). The experimental group received 12 sessions (twice weekly) of standard SGI, whereas the control group received the same protocol with sham irradiation. Pain and HRV were measured before and after each irradiation session. All outcome measures used in the first- and secondhalf treatment courses were analyzed. Results. Pain and HRV outcome measures of the experimental group significantly improved after SGI when compared with the control group in both courses. Considering time and frequency domains, the changes in HRV in the second-half treatment course exceeded those in the first-half treatment course. Pain was significantly associated with postirradiated HRV indices (P < 0.001). Conclusions. Twelve sessions of SGI exerted timedependent positive effects on pain and sympathovagal imbalance. HRV outcomes, including time and frequency domains, were an independent indicator of the clinical efficiency of SGI for treating pain in patients with neuropathic pain.

AB - Background. Neuropathic pain associated with sympathetic overactivity can be effectively relieved by light irradiating the region near stellate ganglion (SGI), applied as an alternative to a conventional sympathetic blockade. The clinical effect of SGI on heart rate variability (HRV) and its association with pain outcomes require investigation. Objective. This study attempted to identify the effects of SGI on pain outcomes and HRV indices and to determine the association between pain and HRV outcomes. Design. A prospective double-blind, randomized study. Setting. An outpatient pain medicine clinic. Subjects and Methods. A total of 44 patients were enrolled and randomized into the experimental group (n 5 22) and control group (n 5 22). The experimental group received 12 sessions (twice weekly) of standard SGI, whereas the control group received the same protocol with sham irradiation. Pain and HRV were measured before and after each irradiation session. All outcome measures used in the first- and secondhalf treatment courses were analyzed. Results. Pain and HRV outcome measures of the experimental group significantly improved after SGI when compared with the control group in both courses. Considering time and frequency domains, the changes in HRV in the second-half treatment course exceeded those in the first-half treatment course. Pain was significantly associated with postirradiated HRV indices (P < 0.001). Conclusions. Twelve sessions of SGI exerted timedependent positive effects on pain and sympathovagal imbalance. HRV outcomes, including time and frequency domains, were an independent indicator of the clinical efficiency of SGI for treating pain in patients with neuropathic pain.

KW - Autonomic Dysfunction

KW - Heart Rate Variability

KW - Linear Polarized Near-Infrared Irradiation

KW - Neuropathic Pain

KW - Stellate Ganglion

UR - http://www.scopus.com/inward/record.url?scp=85019772816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019772816&partnerID=8YFLogxK

U2 - 10.1093/pm/pnw145

DO - 10.1093/pm/pnw145

M3 - Article

C2 - 27452896

AN - SCOPUS:85019772816

VL - 18

SP - 488

EP - 503

JO - Pain Medicine

JF - Pain Medicine

SN - 1526-2375

IS - 3

ER -