Effects of fungal-derived high molecular weight chitosan on 5-fluorouracil-induced adverse reactions

Yih Huei Uen, Ying Jan Wang, Town Ming Hsu, Mei Huei Chen, Hing Yuen Chan, Yuan Soon Ho, Shyr Yi Lin

研究成果: 雜誌貢獻文章

5 引文 斯高帕斯(Scopus)

摘要

The effects of fungal-derived high molecular weight chitosan (HMWC) on the prevention of 5-fluorouracil (5-FU)-induced side-effects were studied in a sarcoma-bearing mice model. 5-FU (12.5mg/kg) was gargled into the mice with or without HMWC (25, 75, and 150mg/kg) every 12 h for consecutive 8 or 16 days in different experiments. The HMWC (25-150 mg/kg) exerted no toxicity and did not interfere with the anti-tumor activity of 5-FU on sarcoma-bearing mice. HMWC in a higher dose (150 mg/kg) partially protected 5-FU-induced cytotoxicity on peripheral leukocytes, lymphocytes, and bone marrow CD-19 positive cells. HMWC reversed the 5-FU suppression of intestine sucrase activity and attenuated the 5-FU-induced diarrhea. Bone marrow cells micronucleus and DNA comet assays demonstrated that HMWC significantly reversed 5-FU-induced genome toxicity to marrow cells. These results suggested that fungal-derived HMWC attenuated the 5-FU-induced bone marrow and gastrointestinal toxicity, and has the potential for clinical applications in the future.

原文英語
頁(從 - 到)458-472
頁數15
期刊Journal of Bioactive and Compatible Polymers
23
發行號5
DOIs
出版狀態已發佈 - 九月 2008

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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