Effects of fibronectin cleaved by neuropsin on cell adhesion and migration

Naoyuki Tani, Kazumasa Matsumoto, Ichiro Ota, Shigetaka Yoshida, Yoshikazu Takada, Sadao Shiosaka, Nariaki Matsuura

研究成果: 雜誌貢獻回顧型文獻同行評審

10 引文 斯高帕斯(Scopus)

摘要

Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, α5B2 cells expressing integrin α5β1 bound less effectively to fibronectin teated with neuropsin than intact fibronectin. In Boyden chamber chemotaxis assays, the fibronectin-induced migration of α5B2 cells was not affected by neuropsin treatment. These findings suggest that neuropsin regulates the local microenvironment by modulating the interaction between cells and fibronectin in ECM.

原文英語
頁(從 - 到)247-251
頁數5
期刊Neuroscience Research
39
發行號2
DOIs
出版狀態已發佈 - 2001
對外發佈

ASJC Scopus subject areas

  • 神經科學 (全部)

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