Effects of Fibrin Sealant on Seroma Reduction for Patients with Breast Cancer Undergoing Axillary Dissection: Meta-Analysis of Randomized Controlled Trials

Ya Ting Chang, Shen Liang Shih, El Wui Loh, Ka Wai Tam

研究成果: 雜誌貢獻回顧型文獻同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background: Seroma formation is common in patients with breast cancer after axillary dissection. Fibrin sealant, containing fibrinogen and thrombin, has been developed to improve wound healing. We conducted a systematic review and meta-analysis to evaluate the efficacy of fibrin sealants in reducing seroma among patients with breast cancer undergoing axillary dissection. Methods: We searched the PubMed, EMBASE, and Cochrane Library databases for randomized controlled trials (RCTs) published up to April 2020. Pooled estimates of the outcomes were computed using a random-effects model. The primary outcomes were incidence and volume of seroma, while the secondary outcomes were volume and duration of drainage, incidence of infection, and length of hospital stay. Results: We reviewed 23 RCTs that included 1640 patients. Compared with the control group, the fibrin sealant group had no significant differences in the incidence of seroma, length of hospital stay, or incidence of surgical site infection. Significant intergroup differences were discovered in lower volume of seroma (weighted mean difference [WMD] − 71.88, 95% confidence interval [CI] − 135.58 to − 8.19), volume of drainage (WMD − 73.24, 95% CI − 107.32 to − 39.15), and duration of drainage (WMD − 0.84, 95% CI − 1.50 to − 0.19). Conclusions: Fibrin sealants provide limited benefits in reducing the volume of seroma and the volume and duration of drainage. Therefore, after shared decision making, surgeons may apply fibrin sealants to patients with breast cancer undergoing axillary dissection.
原文英語
頁(從 - 到)5286-5295
頁數10
期刊Annals of Surgical Oncology
27
發行號13
DOIs
出版狀態已發佈 - 十二月 2020

ASJC Scopus subject areas

  • 手術
  • 腫瘤科

指紋

深入研究「Effects of Fibrin Sealant on Seroma Reduction for Patients with Breast Cancer Undergoing Axillary Dissection: Meta-Analysis of Randomized Controlled Trials」主題。共同形成了獨特的指紋。

引用此