Effects of fibrin glue on hemostasis.

H. Chang, G. J. Wu, W. L. Perng, F. Y. Hwang, C. R. Hung

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)


In order to decrease complications following incomplete hemostasis, we tried to make a safe, efficient and highly concentrated fibrin glue by thawing single-donor fresh frozen plasma. Using a unique animal model, in which arterial bleeding was created, fibrin glue and some related hemostatic agents were tested to evaluate their hemostatic effectiveness. The results demonstrated that: 1) the concomitant use of cryoprecipitate-thrombin tissue glue with adjuvant (aprotinin or calcium chloride) had a better hemostatic effect than the use of cryoprecipitate-thrombin tissue glue alone (p <0.05); 2) impregnation of fibrin glue with a suitable vehicle was advisable to accelerate the coagulation plug formation and to enhance the mechanical strength of the adhesive plug; 3) Gelform, used as a vehicle to hold the fibrin glue, had a more efficient hemostatic effect than gauze, collagen fleece and Surgicel (p <0.05); 4) systemic heparinization attenuated the effectiveness of the hemostatic agents and aggravated the bleeding problem, but a low hematocrit level did not; 5) fibrin glue had its own limitations, especially under systemic heparinization, on hemostatic effectiveness in a high-pressure system. Understanding the characteristics of fibrin glue, as mentioned above, definitely improved the hemostatic effectiveness of the glue, especially after failure of the usual methods of controlling bleeding.

頁(從 - 到)601-607
期刊Journal of the Formosan Medical Association = Taiwan yi zhi
出版狀態已發佈 - 6月 1992

ASJC Scopus subject areas

  • 醫藥 (全部)


深入研究「Effects of fibrin glue on hemostasis.」主題。共同形成了獨特的指紋。