Effects of estradiol on the metabolism of arachidonic acid by aortas and platelets in rats

Chang Wen-Chang, Nakao Junko, Neichi Tomohiro, Orimo Hajime, Murota Sei-Itsu

研究成果: 雜誌貢獻文章同行評審

28 引文 斯高帕斯(Scopus)

摘要

We have previously reported that estradiol treatment stimulates prostacyclin production by cultured rat aortic smooth muscle cells, through the stimulation of fatty acid cyclooxygenase and prostacyclin synthetase activities. In order to see whether estradiol stimulates the fatty acid cyclooxygenase activity in platelets, intact rats were treated with estradiol, and thromboxane biosynthesis in platelets and prostacyclin production by aortas were investigated. Estradiol significantly stimulates prostacyclin production by aortas. However, no significant effect on thromboxane biosynthesis in platelets is observed. Our present results support the idea that estradiol would be a protective hormone in atherosclerotic heart disease.

原文英語
頁(從 - 到)291-297
頁數7
期刊Biochimica et Biophysica Acta - Lipids and Lipid Metabolism
664
發行號2
DOIs
出版狀態已發佈 - 五月 22 1981
對外發佈

ASJC Scopus subject areas

  • 生物化學
  • 生物物理學
  • 內分泌
  • 醫藥 (全部)

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