Effects of epidermal growth factor and its signal transduction inhibitors on apoptosis in human colorectal cancer cells

J. C J Chao, Wen L. Peng, Sheng-Hsuan Chen

研究成果: 雜誌貢獻文章

2 引文 斯高帕斯(Scopus)


Aim: The study investigated if EGF signaling inhibitors, EGF antibody and tyrphostin 51 (a tyrosine kinase inhibitor), mediated the action of EGF on apoptosis and the expression of EGF receptors and p21 (a cyclin-dependent kinase inhibitor) of human colorectal cancer cells. Methods: Human colorectal adenocarcinoma cells (SW480) were incubated with 0.6 mL/L dimethyl sulfoxide (DMSO, the control group), 225 ng/mL (37.5 nmol/L) EGF in 0.6 mL/L DMSO, 225 ng/mL EGF+2.5 μg/mL (17 nmol/L) EGF antibody in 0.6 mL/L DMSO, or 225 ng/mL EGF+215 ng/mL (0.8 μmol/L) tyrphostin 51 in 0.6 mL/L DMSO. Results: After 48 h incubation, the levels of EGF in medium significantly increased (P
頁(從 - 到)540-544
期刊World Journal of Gastroenterology
出版狀態已發佈 - 二月 15 2004


ASJC Scopus subject areas

  • Gastroenterology