Effects of epidermal growth factor and its signal transduction inhibitors on apoptosis in human colorectal cancer cells

J. C J Chao, Wen L. Peng, Sheng-Hsuan Chen

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Aim: The study investigated if EGF signaling inhibitors, EGF antibody and tyrphostin 51 (a tyrosine kinase inhibitor), mediated the action of EGF on apoptosis and the expression of EGF receptors and p21 (a cyclin-dependent kinase inhibitor) of human colorectal cancer cells. Methods: Human colorectal adenocarcinoma cells (SW480) were incubated with 0.6 mL/L dimethyl sulfoxide (DMSO, the control group), 225 ng/mL (37.5 nmol/L) EGF in 0.6 mL/L DMSO, 225 ng/mL EGF+2.5 μg/mL (17 nmol/L) EGF antibody in 0.6 mL/L DMSO, or 225 ng/mL EGF+215 ng/mL (0.8 μmol/L) tyrphostin 51 in 0.6 mL/L DMSO. Results: After 48 h incubation, the levels of EGF in medium significantly increased (P
原文英語
頁(從 - 到)540-544
頁數5
期刊World Journal of Gastroenterology
10
發行號4
出版狀態已發佈 - 二月 15 2004

指紋

Epidermal Growth Factor
Colorectal Neoplasms
Signal Transduction
Apoptosis
Dimethyl Sulfoxide
Cyclin-Dependent Kinase Inhibitor p21
Antibodies
Protein-Tyrosine Kinases
Adenocarcinoma
Control Groups

ASJC Scopus subject areas

  • Gastroenterology

引用此文

Effects of epidermal growth factor and its signal transduction inhibitors on apoptosis in human colorectal cancer cells. / Chao, J. C J; Peng, Wen L.; Chen, Sheng-Hsuan.

於: World Journal of Gastroenterology, 卷 10, 編號 4, 15.02.2004, p. 540-544.

研究成果: 雜誌貢獻文章

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