Effects of early postnatal dexamethasone therapy on calcium homeostasis and bone growth in preterm infants with respiratory distress syndrome

Y. J. Lin, T. F. Yeh, H. C. Lin, J. M. Wu, C. H. Lin, C. Y. Yu

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

The effects of dexamethasone therapy on calcium homeostasis and bone growth were evaluated in 49 infants (24 placebo and 25 dexamethasone) who participated in a double-blind trial of early dexamethasone therapy for the prevention of chronic lung disease. Dexamethasone (0.25 mg kg-1 b.i.d. on d 1-7; mg kg-1 b.i.d. on d 8-14; 0.05 mg kg-1 b.i.d. on d 15-21; 0.02 mg kg- 1 b.i.d. on d 22-28) or saline placebo was given i.v. Serum calcium (Ca), phosphorus (P) and parathyroid hormone (PTH), and the corresponding urinary excretion of calcium (FE(Ca)) and phosphorus (FE(p)) were measured on d 2, 3, 7, 10, 14, 21 and 28 after starting the study. Radiographic evaluations of bone growth were also evaluated. Infants in the dexamethasone group had significantly higher PTH on d 2 (p < 0.01), 7 and 14 (p < 0.05) than infants in the placebo group. The dexamethasone-treated infants also had significantly higher FE(p) on d 2, 7 and 14 (p < 0.05) and lower FE(Ca) on d 7 and 14 (p < 0.05) than control infants. There was no significant difference between the groups in bone growth during the study. It was concluded that early dexamethasone therapy causes a transient elevation in PTH without apparent change in bone growth. The long-term effect remains to be evaluated further.

原文英語
頁(從 - 到)1061-1065
頁數5
期刊Acta Paediatrica, International Journal of Paediatrics
87
發行號10
DOIs
出版狀態已發佈 - 10月 28 1998
對外發佈

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康

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