Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer

Ming Hsien Chien, Lin Shih Shen Chou, Tsung Te Chung, Chien Huang Lin, Ming Yung Chou, Meng Shih Weng, Shun Fa Yang, Mu Kuan Chen

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

Background This study investigates the association between polymorphism in the E-cadherin/CDH1 promoter region and the risk and progression of oral cancer. Methods Genetic polymorphisms of CDH1-160 and -347 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 347 noncancer controls and in 251 patients with oral cancer. Results The statistical analysis showed that subjects with at least 1 varied GA allele of CDH1-347 polymorphic genotypes or combinations of the CDH1-160 CA/-347 GGA, CDH1-160 CC/-347 GGA, or CDH1-160 CC/-347 GAGA genotypes had a significantly higher risk, whereas subjects with CDH1-160 C/A or A/A had a significantly lower risk of developing oral cancer than those with wild-type genotypes. Furthermore, elderly patients with the CDH1-347 G/GA or GA/GA genotype were associated with a higher incidence in lymph node metastasis than were those with the G/G genotype. Conclusions These results suggest that CDH1-347 polymorphisms are associated with increased risks of oral cancer, and may be a predictive factor for tumor lymph node metastasis.
原文英語
頁(從 - 到)405-411
頁數7
期刊Head and Neck
34
發行號3
DOIs
出版狀態已發佈 - 三月 2012

ASJC Scopus subject areas

  • Otorhinolaryngology

指紋 深入研究「Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer」主題。共同形成了獨特的指紋。

  • 引用此