摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 405-411 |
| 頁數 | 7 |
| 期刊 | Head and Neck |
| 卷 | 34 |
| 發行號 | 3 |
| DOIs | |
| 出版狀態 | 已發佈 - 三月 2012 |
指紋
ASJC Scopus subject areas
- Otorhinolaryngology
引用此文
Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer. / Chien, Ming Hsien; Chou, Lin Shih Shen; Chung, Tsung Te; Lin, Chien Huang; Chou, Ming Yung; Weng, Meng Shih; Yang, Shun Fa; Chen, Mu Kuan.
於: Head and Neck, 卷 34, 編號 3, 03.2012, p. 405-411.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Effects of E-cadherin (CDH1) gene promoter polymorphisms on the risk and clinicopathologic development of oral cancer
AU - Chien, Ming Hsien
AU - Chou, Lin Shih Shen
AU - Chung, Tsung Te
AU - Lin, Chien Huang
AU - Chou, Ming Yung
AU - Weng, Meng Shih
AU - Yang, Shun Fa
AU - Chen, Mu Kuan
PY - 2012/3
Y1 - 2012/3
N2 - Background This study investigates the association between polymorphism in the E-cadherin/CDH1 promoter region and the risk and progression of oral cancer. Methods Genetic polymorphisms of CDH1-160 and -347 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 347 noncancer controls and in 251 patients with oral cancer. Results The statistical analysis showed that subjects with at least 1 varied GA allele of CDH1-347 polymorphic genotypes or combinations of the CDH1-160 CA/-347 GGA, CDH1-160 CC/-347 GGA, or CDH1-160 CC/-347 GAGA genotypes had a significantly higher risk, whereas subjects with CDH1-160 C/A or A/A had a significantly lower risk of developing oral cancer than those with wild-type genotypes. Furthermore, elderly patients with the CDH1-347 G/GA or GA/GA genotype were associated with a higher incidence in lymph node metastasis than were those with the G/G genotype. Conclusions These results suggest that CDH1-347 polymorphisms are associated with increased risks of oral cancer, and may be a predictive factor for tumor lymph node metastasis.
AB - Background This study investigates the association between polymorphism in the E-cadherin/CDH1 promoter region and the risk and progression of oral cancer. Methods Genetic polymorphisms of CDH1-160 and -347 were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 347 noncancer controls and in 251 patients with oral cancer. Results The statistical analysis showed that subjects with at least 1 varied GA allele of CDH1-347 polymorphic genotypes or combinations of the CDH1-160 CA/-347 GGA, CDH1-160 CC/-347 GGA, or CDH1-160 CC/-347 GAGA genotypes had a significantly higher risk, whereas subjects with CDH1-160 C/A or A/A had a significantly lower risk of developing oral cancer than those with wild-type genotypes. Furthermore, elderly patients with the CDH1-347 G/GA or GA/GA genotype were associated with a higher incidence in lymph node metastasis than were those with the G/G genotype. Conclusions These results suggest that CDH1-347 polymorphisms are associated with increased risks of oral cancer, and may be a predictive factor for tumor lymph node metastasis.
KW - betel nut chewing
KW - E-cadherin
KW - genetic polymorphism
KW - oral cancer
KW - tobacco consumption
UR - http://www.scopus.com/inward/record.url?scp=84856954811&partnerID=8YFLogxK
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U2 - 10.1002/hed.21746
DO - 10.1002/hed.21746
M3 - Article
C2 - 21472888
AN - SCOPUS:84856954811
VL - 34
SP - 405
EP - 411
JO - Head and Neck
JF - Head and Neck
SN - 1043-3074
IS - 3
ER -