Effects of Double Filtration Plasmapheresis on Nocturnal Respiratory Function in Myasthenic Patients

Jiann Horng Yeh, Chia Mo Lin, Wei Hung Chen, Hou Chang Chiu

研究成果: 雜誌貢獻文章

4 引文 (Scopus)

摘要

Assessment of respiratory function using combined oximetry-cutaneous capnography has never been evaluated in patients with myasthenia gravis (MG). We investigated the effects of double filtration plasmapheresis (DFPP) on respiratory status in 18 MG patients. Results of combined oximetry and transcutaneous capnography, MG scores, and acetylcholine receptor antibody titers before and after DFPP treatment were compared. The respiratory monitoring was performed at three time periods (morning, afternoon, and sleep). Mean MG score was markedly lower after DFPP treatment (5.7) than before treatment (7.9). Before DFPP, the minimum pulse oximetric saturation (SpO2) level obtained during the night session was significantly lower (P=0.0513 and P=0.0199) than the levels obtained during the two daytime sessions. A similar phenomenon was noted for maximum transcutaneous carbon dioxide tension (PtcCO2). After DFPP treatment, the maximum and mean PtcCO2 levels were significantly higher (P=0.0056) in the morning than in the afternoon. Of all the respiratory function parameters measured, only minimum SpO2 levels obtained during morning sessions before DFP treatment differed significantly from those obtained after DFPP treatment (P=0.0322). Overall, however, minimum SpO2 levels as well as mean and maximum PtcCO2 levels improved significantly during sleep after DFPP. In conclusion, we found that respiratory function abnormalities were common in myasthenic patients without clinical respiratory symptoms. DFPP treatment resulted in minimal improvement of respiratory parameters.
原文英語
頁(從 - 到)1076-1079
頁數4
期刊Artificial Organs
37
發行號12
DOIs
出版狀態已發佈 - 十二月 2013

指紋

Plasmapheresis
Muscle Weakness
Myasthenia Gravis
Transcutaneous Blood Gas Monitoring
Capnography
Therapeutics
Sleep
Isoflurophate
Cholinergic Receptors
Antibodies
Carbon Dioxide
Pulse
Carbon dioxide
Monitoring

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

引用此文

Effects of Double Filtration Plasmapheresis on Nocturnal Respiratory Function in Myasthenic Patients. / Yeh, Jiann Horng; Lin, Chia Mo; Chen, Wei Hung; Chiu, Hou Chang.

於: Artificial Organs, 卷 37, 編號 12, 12.2013, p. 1076-1079.

研究成果: 雜誌貢獻文章

Yeh, Jiann Horng ; Lin, Chia Mo ; Chen, Wei Hung ; Chiu, Hou Chang. / Effects of Double Filtration Plasmapheresis on Nocturnal Respiratory Function in Myasthenic Patients. 於: Artificial Organs. 2013 ; 卷 37, 編號 12. 頁 1076-1079.
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abstract = "Assessment of respiratory function using combined oximetry-cutaneous capnography has never been evaluated in patients with myasthenia gravis (MG). We investigated the effects of double filtration plasmapheresis (DFPP) on respiratory status in 18 MG patients. Results of combined oximetry and transcutaneous capnography, MG scores, and acetylcholine receptor antibody titers before and after DFPP treatment were compared. The respiratory monitoring was performed at three time periods (morning, afternoon, and sleep). Mean MG score was markedly lower after DFPP treatment (5.7) than before treatment (7.9). Before DFPP, the minimum pulse oximetric saturation (SpO2) level obtained during the night session was significantly lower (P=0.0513 and P=0.0199) than the levels obtained during the two daytime sessions. A similar phenomenon was noted for maximum transcutaneous carbon dioxide tension (PtcCO2). After DFPP treatment, the maximum and mean PtcCO2 levels were significantly higher (P=0.0056) in the morning than in the afternoon. Of all the respiratory function parameters measured, only minimum SpO2 levels obtained during morning sessions before DFP treatment differed significantly from those obtained after DFPP treatment (P=0.0322). Overall, however, minimum SpO2 levels as well as mean and maximum PtcCO2 levels improved significantly during sleep after DFPP. In conclusion, we found that respiratory function abnormalities were common in myasthenic patients without clinical respiratory symptoms. DFPP treatment resulted in minimal improvement of respiratory parameters.",
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