Effects of different extracellular matrices and growth factor immobilization on biodegradability and biocompatibility of macroporous bacterial cellulose

Yung Kai Lin, Ko Hua Chen, Keng Liang Ou, Min Liu

研究成果: 雜誌貢獻文章

33 引文 斯高帕斯(Scopus)

摘要

To improve the biocompatibility of bacterial cellulose hydrogel (BCHG), different extracellular matrices (ECMs; collagen, elastin, and hyaluronan) and growth factors (B-FGF, H-EGF, and KGF) were immobilized onto macroporous BCHG. The microstructure of BCHG had inter-connective channels that were well-integrated with the alginate gel. The alginate gel formed a semi-penetrate hydrogel that allowed the ECM and growth factor to diffuse under physiological conditions. The H-EGF and collagen-modified BCHG supported the growth of human skin fibroblast. The improved BCHG was biocompatible and exhibited desirable skin substitute characteristics that could be used as a deliver vehicle for therapeutic compounds during wound healing.

原文英語
頁(從 - 到)508-518
頁數11
期刊Journal of Bioactive and Compatible Polymers
26
發行號5
DOIs
出版狀態已發佈 - 九月 2011

ASJC Scopus subject areas

  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry
  • Bioengineering

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