Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice

Pao Pao Yang, Geng Chang Yeh, Eagle Yi Kung Huang, Ping Yee Law, Horace H. Loh, Pao Luh Tao

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Background: Neuropathic pain is a very troublesome and difficult pain to treat. Although opioids are the best analgesics for cancer and surgical pain in clinic, only oxycodone among opioids shows better efficacy to alleviate neuropathic pain. However, many side effects associated with the use of oxycodone render the continued use of it in neuropathic pain treatment undesirable. Hence, we explored whether dextromethorphan (DM, a known N-methyl-D-aspartate receptor antagonist with neuroprotective properties) could potentiate the anti-allodynic effect of oxycodone and underlying mechanisms regarding to glial cells (astrocytes and microglia) activation and proinflammatory cytokines release in a spinal nerve injury (SNL) mice model. Results: Oxycodone produced a dose-dependent anti-allodynic effect. Co-administration of DM at a dose of 10 mg/kg (i.p.) (DM10) which had no anti-allodynic effect by itself enhanced the acute oxycodone (1 mg/kg, s.c.) effect. When the chronic anti-allodynic effects were examined, co-administration of DM10 also significantly enhanced the oxycodone effect at 3 mg/kg. Furthermore, oxycodone decreased SNL-induced activation of glial cells (astrocytes and microglia) and plasma levels of proinflammatory cytokines (IL-6, IL-1β and TNF-aα). Co-administration of DM10 potentiated these effects of oxycodone. Conclusion: The combined use of DM with oxycodone may have therapeutic potential for decreasing the effective dose of oxycodone on the treatment of neuropathic pain. Attenuation of the glial activation and proinflammatory cytokines in the spinal cord may be important mechanisms for these effects of DM.

原文英語
期刊Journal of Biomedical Science
DOIs
出版狀態接受/付印 - 九月 22 2015

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

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    Yang, P. P., Yeh, G. C., Huang, E. Y. K., Law, P. Y., Loh, H. H., & Tao, P. L. (認可的出版社/出版中). Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice. Journal of Biomedical Science. https://doi.org/10.1186/s12929-015-0186-3