Effects of dexmedetomidine on the isolated rat tracheal smooth muscle

Hung Chi Chang, Yih-Giun Cherng, Chih Ting Hsu, Meng Chi Liu, Hsing-Won Wang

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

Background/Purpose: Intranasally administered dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been found to an effective premedication in children. However, the effect of delivering dexmedetomidine directly into the tracheal smooth muscle through inhalation has not been adequately explored. The objective of this study was to determine the effects of dexmedetomidine on the isolated rat tracheal smooth muscle invitro. Methods: A portion of rat trachea (5mm in length) was mounted in a muscle bath filled with 30mL of Krebs solution at 37°C. The following effects of dexmedetomidine were assessed: (1) effect on the tracheal smooth muscle resting tension, (2) effect on contraction caused by 10-6M methacholine, and (3) effect on electrically induced tracheal smooth muscle contractions. Results: Dexmedetomidine elicited a negligible effect on the basal tension of the trachea as its concentration was increased. Dexmedetomidine caused a concentration-dependent relaxation in the trachealis muscle precontracted with 10-6M methacholine, but did not affect the contractile response to electrical field stimulation. Conclusion: The results of this study suggest that high concentrations of dexmedetomidine might have an antispasmodic effect on the tracheal smooth muscle.

原文英語
頁(從 - 到)139-142
頁數4
期刊Journal of Experimental and Clinical Medicine(Taiwan)
5
發行號4
DOIs
出版狀態已發佈 - 八月 2013

指紋

Dexmedetomidine
Smooth Muscle
Methacholine Chloride
Trachea
Parasympatholytics
Muscles
Muscle Tonus
Premedication
Muscle Contraction
Baths
Adrenergic Receptors
Inhalation
Electric Stimulation

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Effects of dexmedetomidine on the isolated rat tracheal smooth muscle. / Chang, Hung Chi; Cherng, Yih-Giun; Hsu, Chih Ting; Liu, Meng Chi; Wang, Hsing-Won.

於: Journal of Experimental and Clinical Medicine(Taiwan), 卷 5, 編號 4, 08.2013, p. 139-142.

研究成果: 雜誌貢獻文章

@article{9f7abee5d1064a88936b128d5785d5fd,
title = "Effects of dexmedetomidine on the isolated rat tracheal smooth muscle",
abstract = "Background/Purpose: Intranasally administered dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been found to an effective premedication in children. However, the effect of delivering dexmedetomidine directly into the tracheal smooth muscle through inhalation has not been adequately explored. The objective of this study was to determine the effects of dexmedetomidine on the isolated rat tracheal smooth muscle invitro. Methods: A portion of rat trachea (5mm in length) was mounted in a muscle bath filled with 30mL of Krebs solution at 37°C. The following effects of dexmedetomidine were assessed: (1) effect on the tracheal smooth muscle resting tension, (2) effect on contraction caused by 10-6M methacholine, and (3) effect on electrically induced tracheal smooth muscle contractions. Results: Dexmedetomidine elicited a negligible effect on the basal tension of the trachea as its concentration was increased. Dexmedetomidine caused a concentration-dependent relaxation in the trachealis muscle precontracted with 10-6M methacholine, but did not affect the contractile response to electrical field stimulation. Conclusion: The results of this study suggest that high concentrations of dexmedetomidine might have an antispasmodic effect on the tracheal smooth muscle.",
keywords = "Dexmedetomidine, Electrical field stimulation, Methacholine, Smooth muscle, Trachea",
author = "Chang, {Hung Chi} and Yih-Giun Cherng and Hsu, {Chih Ting} and Liu, {Meng Chi} and Hsing-Won Wang",
year = "2013",
month = "8",
doi = "10.1016/j.jecm.2013.06.013",
language = "English",
volume = "5",
pages = "139--142",
journal = "Journal of Experimental and Clinical Medicine",
issn = "1878-3317",
publisher = "Elsevier Taiwan LLC",
number = "4",

}

TY - JOUR

T1 - Effects of dexmedetomidine on the isolated rat tracheal smooth muscle

AU - Chang, Hung Chi

AU - Cherng, Yih-Giun

AU - Hsu, Chih Ting

AU - Liu, Meng Chi

AU - Wang, Hsing-Won

PY - 2013/8

Y1 - 2013/8

N2 - Background/Purpose: Intranasally administered dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been found to an effective premedication in children. However, the effect of delivering dexmedetomidine directly into the tracheal smooth muscle through inhalation has not been adequately explored. The objective of this study was to determine the effects of dexmedetomidine on the isolated rat tracheal smooth muscle invitro. Methods: A portion of rat trachea (5mm in length) was mounted in a muscle bath filled with 30mL of Krebs solution at 37°C. The following effects of dexmedetomidine were assessed: (1) effect on the tracheal smooth muscle resting tension, (2) effect on contraction caused by 10-6M methacholine, and (3) effect on electrically induced tracheal smooth muscle contractions. Results: Dexmedetomidine elicited a negligible effect on the basal tension of the trachea as its concentration was increased. Dexmedetomidine caused a concentration-dependent relaxation in the trachealis muscle precontracted with 10-6M methacholine, but did not affect the contractile response to electrical field stimulation. Conclusion: The results of this study suggest that high concentrations of dexmedetomidine might have an antispasmodic effect on the tracheal smooth muscle.

AB - Background/Purpose: Intranasally administered dexmedetomidine, a highly selective α2-adrenoceptor agonist, has been found to an effective premedication in children. However, the effect of delivering dexmedetomidine directly into the tracheal smooth muscle through inhalation has not been adequately explored. The objective of this study was to determine the effects of dexmedetomidine on the isolated rat tracheal smooth muscle invitro. Methods: A portion of rat trachea (5mm in length) was mounted in a muscle bath filled with 30mL of Krebs solution at 37°C. The following effects of dexmedetomidine were assessed: (1) effect on the tracheal smooth muscle resting tension, (2) effect on contraction caused by 10-6M methacholine, and (3) effect on electrically induced tracheal smooth muscle contractions. Results: Dexmedetomidine elicited a negligible effect on the basal tension of the trachea as its concentration was increased. Dexmedetomidine caused a concentration-dependent relaxation in the trachealis muscle precontracted with 10-6M methacholine, but did not affect the contractile response to electrical field stimulation. Conclusion: The results of this study suggest that high concentrations of dexmedetomidine might have an antispasmodic effect on the tracheal smooth muscle.

KW - Dexmedetomidine

KW - Electrical field stimulation

KW - Methacholine

KW - Smooth muscle

KW - Trachea

UR - http://www.scopus.com/inward/record.url?scp=84883449796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883449796&partnerID=8YFLogxK

U2 - 10.1016/j.jecm.2013.06.013

DO - 10.1016/j.jecm.2013.06.013

M3 - Article

VL - 5

SP - 139

EP - 142

JO - Journal of Experimental and Clinical Medicine

JF - Journal of Experimental and Clinical Medicine

SN - 1878-3317

IS - 4

ER -