Effects of cocaine on human nasal mucosa

S. H. Wang, H. W. Wang, J. Y. Wang

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

The effects of cocaine on the contractile response of isolated human nasal mucosal blood vessels to field stimulation and methoxamine were investigated. Results showed that cocaine antagonized methoxamine and inhibited field stimulation. The drug increased resting tension in human nasal mucosa in vitro through direct actions and potentiated mucosal contractions by norepinephrine and epinephrine. The study indicated that high concentrations of cocaine may actually antagonize α-adrenoceptors, but these concentrations are not necessary in eliciting desired degrees of vasoconstriction in nasal blood vessels while being applied as a local anesthetic.
原文英語
頁(從 - 到)245-248
頁數4
期刊European Archives of Oto-Rhino-Laryngology
250
發行號4
DOIs
出版狀態已發佈 - 七月 1993
對外發佈

ASJC Scopus subject areas

  • 耳鼻咽喉科

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