Effects of cimetidine on the metabolic disposition of isoniazid in rabbits

K. Y. Hsu, Y. S. Uang

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1 引文 斯高帕斯(Scopus)

摘要

Effects of cimetidine on the metabolic disposition of isoniazid (INH) were investigated in rabbits administered with 0.109 mmol kg-1 of either INH, acetylisoniazid (AcINH), isonicotinic acid (INA), sodium α-ketoglutarate isonicotinoyl hydrazone (INH-K) or sodium pyruvate isonicotinoyl hydrazone (INH-P). Oral cimetidine (50 mg kg-1 given 1 h prior to the other drugs significantly (p -1 kg-1. The mean formation fraction (F) of INA formed from the hydrolysis of INH and AcINH after administration of INH was significantly decreased (p

原文英語
頁(從 - 到)307-314
頁數8
期刊Asia Pacific Journal of Pharmacology
4
發行號4
出版狀態已發佈 - 1989

ASJC Scopus subject areas

  • 藥理

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