Effects of chronic exposure to formaldehyde on micronucleus rate of bone marrow cells in male mice

Yunru Liu, Dee Yu, Sha Xiao

研究成果: 雜誌貢獻文章同行評審

5 引文 斯高帕斯(Scopus)

摘要

Formaldehyde (FA) is the major volatile organic chemical (VOC) present in indoor air, and a constituent known to be associated with sick building syndrome. In the present study, mice were exposed to different concentrations of FA (0, 1, 10 mg/m3) through static inhalation for 2 hours per day for 20 weeks. The polychromatic erythrocytes/normochromatic erythrocyte (PCE/NCE) ratio and the micronucleus rates in bone marrow cells were detected. Data indicated that the PCE/NCE ratio in two FA exposure groups were statistically significant lower than the negative control group (P <0.05), and the micronucleus rate in two FA exposure groups were not significantly higher than the control group (P>0.05). These results suggest that chronic static inhalation of FA can reduce the ratio of PCE/NCE in the mice bone marrow, but the effects to the mice bone micronucleus rate are not sure.

原文英語
頁(從 - 到)933-935
頁數3
期刊Journal of the Pakistan Medical Association
67
發行號6
出版狀態已發佈 - 一月 1 2017
對外發佈

ASJC Scopus subject areas

  • 醫藥 (全部)

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