Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity

Y. J. Tsai, H. Abe, H. Maruta, T. Hatano, H. Nishina, H. Sakagami, T. Okuda, S. I. Tanuma

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)

摘要

Three classes of chemically defined tannins, gallotannins, ellagitannins and condensed tannins were examined for their inhibitory activities against purified poly(ADP-ribose) glycohydrolase. Ellagitannins showed higher inhibitory activities than gallotannins. In contrant, condensed tannins, which consist of an epicathechin gallate (ECG) oligomer without a glucose core were not appreciably inhibitory. Kinetic analysis revealed that the inhibition of ellagitannins was competitive with respect to the substrate poly(ADP-ribose), whereas gallotannins exhibited mixed-type inhibition. These results suggest that conjugation with glucose of hexahydroxydiphenoyl (HHDP) group, which is a unique component of ellagitannins, potentiated the inhibitory activity, and that the structure of ellagitannins may have a functional domain which competes with poly(ADP-ribose) on the poly(ADP-ribose) glycohydrolase molecule.
原文英語
頁(從 - 到)889-897
頁數9
期刊Biochemistry International
24
發行號5
出版狀態已發佈 - 1991

ASJC Scopus subject areas

  • 生物化學

指紋

深入研究「Effects of chemically defined tannins on Poly(ADP-ribose) glycohydrolase activity」主題。共同形成了獨特的指紋。

引用此