@article{18d3baa38ae44b7e8b7d8d3b46850f42,
title = "Effects of calorie restriction with n-3 long-chain polyunsaturated fatty acids on metabolic syndrome severity in obese subjects: A randomize-controlled trial",
abstract = "Metabolic syndrome (MetS) increases the risk of type 2 DM and cardiovascular disease. We here evaluated the effects of a calorie-restriction diet with 2.13 g/day n-3 long-chain polyunsaturated fatty acid supplementation in MetS patients. The 188 participants were randomly assigned one of four calorie-restriction diets for 12 weeks: calorie-restriction (n = 44), calorie-restriction meal replacement (n = 45), calorie-restriction with fish oil (n = 44), or calorie-restriction meal replacement with fish oil (n = 44); 179 participants completed the trial. After treatment, all groups had significant reduction in waist circumference, blood pressure, and cardiometabolic parameters. Results indicate that long-chain polyunsaturated fatty acid (LC-PUFA) supplementation under calorie-restriction exert beneficial effects on metabolic parameters.",
keywords = "Metabolic syndrome, N-3 long-chain polyunsaturated fatty acids, N-6/n-3 ratio",
author = "Lee, {Hsiu Chuan} and Cheng, {Wen Yi} and Hsu, {Yi Hao} and Su, {Hsiu Yueh} and Huang, {Brian E T G} and Yen-Kuang Lin and Chan, {Wing P.} and Chien-Tien Su and Shih-Yi Huang",
note = "Funding Information: The authors thank Miss Yu-Ru Guo and Chun-Jung Kao for their assistance, and the staff of Taipei Medical University Hospital and Wan Fan Hospital in Taiwan for their assistance throughout this study. This study was supported by Herbalife Taiwan Co. Ltd. and partial grants from the Ministry of Science and Technology, Taiwan ( NSC101-2320-B-038-020-MY2 , NSC101-2811-B-038-006 , NSC102-2313-B-038-003-MY2 , and MOST103-2320-B-038-012-MY3 ). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",
year = "2015",
doi = "10.1016/j.jff.2015.01.040",
language = "English",
volume = "19",
pages = "929--940",
journal = "Journal of Functional Foods",
issn = "1756-4646",
publisher = "Elsevier Ltd",
}