Effects of calcitriol on type 5b tartrate-resistant acid phosphatase and interleukin-6 in secondary hyperparathyroidism

Kuo Cheng Lu, Chin Feng Tseng, Chia Chao Wu, Lai King Yeung, Jin Shuen Chen, Tsu Yi Chao, Anthony J. Janckila, Lung T. Yam, Pauling Chu

研究成果: 雜誌貢獻文章

8 引文 斯高帕斯(Scopus)

摘要

Background/Aims: Secondary hyperparathyroidism (SHP) is characterized by high bone turnover and elevated serum bone remodeling markers. Elevation of serum interleukin-6 (IL-6) levels is also characteristic of end-stage renal disease. This study investigates the effects of intravenous calcitriol on serum bone resorptive markers, namely, type 5b tartrate-resistant acid phosphatase (TRACP5b) and IL-6 in patients with SHP. Methods: Intravenous calcitriol therapy was given for 16 weeks to 24 patients on maintenance hemodialysis with plasma intact parathyroid hormone (iPTH) levels >300 pg/ml. Blood was drawn at baseline and every 4 weeks for 16 weeks for determination of the levels of biochemical parameters, iPTH, IL-6 and bone remodeling markers, including bone-specific alkaline phosphatase (bAP) and TRACP5b. Results: Only 21 patients responded to the calcitriol therapy, with significant decrements in serum iPTH after 4 weeks of therapy and thereafter. After 16 weeks of calcitriol therapy, 21 patients had significant decrements in serum iPTH (707.9 ± 317.8 vs. 205.0 ± 63.1 pg/ml, p <0.01). Prior to treatment, a significant correlation was found between increased levels of serum iPTH and IL-6 levels (r = 0.45, p <0.05). After treatment, there was also a significant and parallel lowering of levels of serum iPTH, IL-6 (8.52 ± 3.59 vs. 7.24 ± 2.81 pg/ml, p <0.01), bAP (54.68 ± 36.17 vs. 24.55 ± 13.84 U/l, p <0.01) and TRACP5b (3.41 ± 1.89 vs. 1.80 ± 0.55 U/l, p <0.01). Our results additionally showed significant positive correlationsbetween baseline levels of serum IL-6 and those of iPTH, bAP and TRACP5b. After 16 weeks of calcitriol treatment, the correlation between IL-6 and iPTH levels lost significance but levels of serum IL-6, bAP and TRACP5b remained significantly correlated. Conclusions: Elevated levels of serum IL-6 and bone remodeling markers, namely, bAP and TRACP5b which are common features of SHP, are effectively suppressed by calcitriol therapy. This indicates that hyperparathyroidism not only accelerates bone remodeling but may also aggravate inflammation in patients on maintenance hemodialysis.

原文英語
頁(從 - 到)423-430
頁數8
期刊Blood Purification
24
發行號5-6
DOIs
出版狀態已發佈 - 十二月 2006
對外發佈Yes

ASJC Scopus subject areas

  • Nephrology
  • Hematology

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    Lu, K. C., Tseng, C. F., Wu, C. C., Yeung, L. K., Chen, J. S., Chao, T. Y., Janckila, A. J., Yam, L. T., & Chu, P. (2006). Effects of calcitriol on type 5b tartrate-resistant acid phosphatase and interleukin-6 in secondary hyperparathyroidism. Blood Purification, 24(5-6), 423-430. https://doi.org/10.1159/000094899