Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma

Mei Ju Chen, Ching Yu Cheng, Yen Cheng Chen, Ching Kuang Chou, Wen-Ming Hsu

研究成果: 雜誌貢獻文章

10 引文 (Scopus)

摘要

Purpose: The aim of this study was to investigate the effects of bimatoprost 0.03% on ocular hemodynamics in patients with normal tension glaucoma (NTG). Methods: Twenty-two (22) patients with NTG were consecutively recruited. After basic eye examination and diurnal intraocular pressure (IOP) measurement, color Doppler imaging was used to measure the peak systolic and end diastolic velocities and resistive index of the central retinal, lateral posterior ciliary, and medial posterior ciliary arteries. Patients received bimatoprost 0.03% for 4 weeks, and these measurements were then repeated. The worse eye of each NTG patient was used in the statistical analysis. Results: Bimatoprost 0.03% significantly reduced mean IOP from 15.1 ± 3.8 mmHg at baseline to 12.0 ±2.9 mmHg after treatment in our sample of NTG patients (P < 0.001). No significant changes in blood velocities or resistance indices were observed in the retrobulbar vessels after the 4-week treatment Conclusions: Topical bimatoprost 0.03% significantly reduced IOP in our NTG patients without causing significant hemodynamic changes in the retrobulbar vessels.

原文英語
頁(從 - 到)188-193
頁數6
期刊Journal of Ocular Pharmacology and Therapeutics
22
發行號3
DOIs
出版狀態已發佈 - 六月 1 2006
對外發佈Yes

指紋

Low Tension Glaucoma
Hemodynamics
Intraocular Pressure
Ciliary Arteries
Bimatoprost
Color
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology
  • Pharmacology
  • Pharmacology (medical)

引用此文

Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma. / Chen, Mei Ju; Cheng, Ching Yu; Chen, Yen Cheng; Chou, Ching Kuang; Hsu, Wen-Ming.

於: Journal of Ocular Pharmacology and Therapeutics, 卷 22, 編號 3, 01.06.2006, p. 188-193.

研究成果: 雜誌貢獻文章

Chen, Mei Ju ; Cheng, Ching Yu ; Chen, Yen Cheng ; Chou, Ching Kuang ; Hsu, Wen-Ming. / Effects of bimatoprost 0.03% on ocular hemodynamics in normal tension glaucoma. 於: Journal of Ocular Pharmacology and Therapeutics. 2006 ; 卷 22, 編號 3. 頁 188-193.
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abstract = "Purpose: The aim of this study was to investigate the effects of bimatoprost 0.03{\%} on ocular hemodynamics in patients with normal tension glaucoma (NTG). Methods: Twenty-two (22) patients with NTG were consecutively recruited. After basic eye examination and diurnal intraocular pressure (IOP) measurement, color Doppler imaging was used to measure the peak systolic and end diastolic velocities and resistive index of the central retinal, lateral posterior ciliary, and medial posterior ciliary arteries. Patients received bimatoprost 0.03{\%} for 4 weeks, and these measurements were then repeated. The worse eye of each NTG patient was used in the statistical analysis. Results: Bimatoprost 0.03{\%} significantly reduced mean IOP from 15.1 ± 3.8 mmHg at baseline to 12.0 ±2.9 mmHg after treatment in our sample of NTG patients (P < 0.001). No significant changes in blood velocities or resistance indices were observed in the retrobulbar vessels after the 4-week treatment Conclusions: Topical bimatoprost 0.03{\%} significantly reduced IOP in our NTG patients without causing significant hemodynamic changes in the retrobulbar vessels.",
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