Effects of antibacterial nanostructured composite films on vascular stents: Hemodynamic behaviors, microstructural characteristics, and biomechanical properties

Han Yi Cheng, Wen Tien Hsiao, Li Hsiang Lin, Ya Ju Hsu, Andi Wardihan Sinrang, Keng Liang Ou

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

The purpose of this research was to investigate stresses resulting from different thicknesses and compositions of hydrogenated Cu-incorporated diamond-like carbon (a-C:H/Cu) films at the interface between vascular stent and the artery using three-dimensional reversed finite element models (FEMs). Blood flow velocity variation in vessels with plaques was examined by angiography, and the a-C:H/Cu films were characterized by transmission electron microscopy to analyze surface morphology. FEMs were constructed using a computer-aided reverse design system, and the effects of antibacterial nanostructured composite films in the stress field were investigated. The maximum stress in the vascular stent occurred at the intersections of net-like structures. Data analysis indicated that the stress decreased by 15% in vascular stents with antibacterial nanostructured composite films compared to the control group, and the stress decreased with increasing film thickness. The present results confirmed that antibacterial nanostructured composite films improve the biomechanical properties of vascular stents and release abnormal stress to prevent restenosis. The results of the present study offer the clinical benefit of inducing superior biomechanical behavior in vascular stents.

原文英語
頁(從 - 到)269-275
頁數7
期刊Journal of Biomedical Materials Research - Part A
103
發行號1
DOIs
出版狀態已發佈 - 一月 1 2015

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Ceramics and Composites
  • Metals and Alloys
  • Medicine(all)

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