Effects of Anoectochilus formosanus Hayata extract and glucocorticoid on lung maturation in preterm rats

C. M. Chen, Leng-Fang Wang, K. T. Cheng, Hsun-Hui Hsu, B. Gau, B. Su

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

We investigated the effects of maternal administration of Anoectochilus formosanus extract and dexamethasone on lung maturation in preterm rats. A. formosanus group mothers were tube-fed A. formosanus extract (300 mg/kg body wt./day) for 7 days from days 12-18 of gestation. Dexamethasone group mothers were injected intraperitoneally with dexamethasone (0.2 mg/kg body wt.) in saline on day 18 of gestation. Control group mothers were similarly injected with saline alone. On day 19 of gestation, fetuses were delivered by cesarean section. A. formosanus treatment significantly increased the fetal lung/body weight ratio, as compared to dexamethasone treatment. Saturated phosphatidylcholine levels in fetal lung tissue and growth hormone levels in maternal serum were significantly increased in the A. formosanus- and dexamethasone-treated groups as compared to controls. The histological appearance of preterm rat lungs revealed extensive branching of intermediate airways, denser mesenchyme, and more epithelial tubules in the dexamethasone and A. formosanus groups as compared with the control group. These results suggest that antenatal A. formosanus treatment may play a role in accelerating fetal rat lung maturation.
原文英語
頁(從 - 到)509-515
頁數7
期刊Phytomedicine
11
發行號6
DOIs
出版狀態已發佈 - 九月 2004

指紋

glucocorticoids
Dexamethasone
Glucocorticoids
dexamethasone
Rats
lungs
Lung
rats
extracts
Pregnancy
pregnancy
Fetus
Mothers
Control Groups
Fetal Weight
Mesoderm
tube feeding
Fetal Development
cesarean section
Phosphatidylcholines

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

引用此文

Effects of Anoectochilus formosanus Hayata extract and glucocorticoid on lung maturation in preterm rats. / Chen, C. M.; Wang, Leng-Fang; Cheng, K. T.; Hsu, Hsun-Hui; Gau, B.; Su, B.

於: Phytomedicine, 卷 11, 編號 6, 09.2004, p. 509-515.

研究成果: 雜誌貢獻文章

Chen, C. M. ; Wang, Leng-Fang ; Cheng, K. T. ; Hsu, Hsun-Hui ; Gau, B. ; Su, B. / Effects of Anoectochilus formosanus Hayata extract and glucocorticoid on lung maturation in preterm rats. 於: Phytomedicine. 2004 ; 卷 11, 編號 6. 頁 509-515.
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