Effects of amphetamine on human nasal mucosa

H. W. Wang, S. H. Wang, J. Y. Wang, W. Y. Su

研究成果: 雜誌貢獻文章同行評審

3 引文 斯高帕斯(Scopus)

摘要

The present study was devised to determine the effects of amphetamine on the sympathetic function of human nasal mucosa. A tissue bath method was employed on the vitro preparations of nasal turbinate mucosa from adult patients with nasal allergies or hypertrophic rhinitis. The effects of amphetamine on the contractile response of isolated human nasal mucosal blood vessels were investigated following electrical field stimulation and methoxamine. The results showed that amphetamine inhibited field stimulation and antagonized the effects on mucosal contraction induced by methoxamine. Likewise, the drug increased mucosal basal tension but had local drug toxicity when a 10-4 M solution was used. Amphetamine could potentiate mucosal contraction induced by norepinephrine or epinephrine. The study indicated that amphetamine may increase sympathetic function by potentiating the effect of norepinephrine and that high concentrations of amphetamine may actually antagonize α-adrenoceptors.
原文英語
頁(從 - 到)498-500
頁數3
期刊European Archives of Oto-Rhino-Laryngology
253
發行號8
出版狀態已發佈 - 1996
對外發佈Yes

ASJC Scopus subject areas

  • Otorhinolaryngology

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