Effects of aging and hypertension on cerebral ischemic susceptibility: Evidenced by MR diffusion-perfusion study in rat

Tsong Hai Lee, Ho Ling Liu, Shun Tai Yang, Jen Tsung Yang, Mei Yu Yeh, Jr Rung Lin

研究成果: 雜誌貢獻文章

17 引文 (Scopus)

摘要

Aging is the most significant non-modifiable risk factor and hypertension is the most significant modifiable risk factor for ischemic stroke. We used magnetic resonance imaging (MRI) to investigate the evidence of ischemic susceptibility after aging and hypertension. Four groups of rat were studied: young normotensive Wistar-Kyoto (WKY) rat, aged normotensive WKY rat, young spontaneously hypertensive rat (SHR) and aged SHR. Brain images were acquired at a 3.0T Tim-Trio MRI system. For diffusion-weighted images, apparent diffusion coefficient (ADC) was measured. Relative cerebral blood flow (CBF) was also calculated. Cerebral ischemic susceptibility was examined by using ischemic model of bilateral common carotid artery occlusion. In the MRI study of non-ischemic rat, aged SHR had significantly higher ADC (P<0.01) and significantly lower CBF (P<0.01) in the parietal cortex, but aged WKY rat had only significantly lower CBF (P<0.01) when compared with young WKY rat. The ADC/CBF ratio in the parietal cortex was significantly higher in aged SHR when compared with young WKY rat, young SHR and aged WKY rat (P<0.01, P<0.05, P<0.05, respectively) suggesting a significant diffusion-perfusion disparity in aged SHR. After bilateral common carotid artery occlusion, there was significantly larger damage in the parietal cortex of aged SHR when compared with young WKY rat, young SHR and aged WKY rat (all P<0.05), but not in the hippocampus and thalamus (P> 0.05). Our study demonstrated a significantly increased ADC value and reduced CBF in the ischemia-vulnerable cortical area. This cerebral diffusion-perfusion disparity is seen mainly in aged rat and can be more evident if associated with hypertension indicating an increased susceptibility of brain tissue to ischemic injury.

原文英語
頁(從 - 到)314-321
頁數8
期刊Experimental Neurology
227
發行號2
DOIs
出版狀態已發佈 - 二月 2011

指紋

Perfusion
Hypertension
Cerebrovascular Circulation
Inbred SHR Rats
Inbred WKY Rats
Magnetic Resonance Imaging
Common Carotid Artery
Brain
Ischemia
Stroke
Wounds and Injuries

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

引用此文

Effects of aging and hypertension on cerebral ischemic susceptibility : Evidenced by MR diffusion-perfusion study in rat. / Lee, Tsong Hai; Liu, Ho Ling; Yang, Shun Tai; Yang, Jen Tsung; Yeh, Mei Yu; Lin, Jr Rung.

於: Experimental Neurology, 卷 227, 編號 2, 02.2011, p. 314-321.

研究成果: 雜誌貢獻文章

Lee, Tsong Hai ; Liu, Ho Ling ; Yang, Shun Tai ; Yang, Jen Tsung ; Yeh, Mei Yu ; Lin, Jr Rung. / Effects of aging and hypertension on cerebral ischemic susceptibility : Evidenced by MR diffusion-perfusion study in rat. 於: Experimental Neurology. 2011 ; 卷 227, 編號 2. 頁 314-321.
@article{99d78760525a4d52b60f484bb38a32eb,
title = "Effects of aging and hypertension on cerebral ischemic susceptibility: Evidenced by MR diffusion-perfusion study in rat",
abstract = "Aging is the most significant non-modifiable risk factor and hypertension is the most significant modifiable risk factor for ischemic stroke. We used magnetic resonance imaging (MRI) to investigate the evidence of ischemic susceptibility after aging and hypertension. Four groups of rat were studied: young normotensive Wistar-Kyoto (WKY) rat, aged normotensive WKY rat, young spontaneously hypertensive rat (SHR) and aged SHR. Brain images were acquired at a 3.0T Tim-Trio MRI system. For diffusion-weighted images, apparent diffusion coefficient (ADC) was measured. Relative cerebral blood flow (CBF) was also calculated. Cerebral ischemic susceptibility was examined by using ischemic model of bilateral common carotid artery occlusion. In the MRI study of non-ischemic rat, aged SHR had significantly higher ADC (P<0.01) and significantly lower CBF (P<0.01) in the parietal cortex, but aged WKY rat had only significantly lower CBF (P<0.01) when compared with young WKY rat. The ADC/CBF ratio in the parietal cortex was significantly higher in aged SHR when compared with young WKY rat, young SHR and aged WKY rat (P<0.01, P<0.05, P<0.05, respectively) suggesting a significant diffusion-perfusion disparity in aged SHR. After bilateral common carotid artery occlusion, there was significantly larger damage in the parietal cortex of aged SHR when compared with young WKY rat, young SHR and aged WKY rat (all P<0.05), but not in the hippocampus and thalamus (P> 0.05). Our study demonstrated a significantly increased ADC value and reduced CBF in the ischemia-vulnerable cortical area. This cerebral diffusion-perfusion disparity is seen mainly in aged rat and can be more evident if associated with hypertension indicating an increased susceptibility of brain tissue to ischemic injury.",
keywords = "Aging, Blood pressure, Cerebral ischemia, Magnetic resonance imaging",
author = "Lee, {Tsong Hai} and Liu, {Ho Ling} and Yang, {Shun Tai} and Yang, {Jen Tsung} and Yeh, {Mei Yu} and Lin, {Jr Rung}",
year = "2011",
month = "2",
doi = "10.1016/j.expneurol.2010.12.003",
language = "English",
volume = "227",
pages = "314--321",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Effects of aging and hypertension on cerebral ischemic susceptibility

T2 - Evidenced by MR diffusion-perfusion study in rat

AU - Lee, Tsong Hai

AU - Liu, Ho Ling

AU - Yang, Shun Tai

AU - Yang, Jen Tsung

AU - Yeh, Mei Yu

AU - Lin, Jr Rung

PY - 2011/2

Y1 - 2011/2

N2 - Aging is the most significant non-modifiable risk factor and hypertension is the most significant modifiable risk factor for ischemic stroke. We used magnetic resonance imaging (MRI) to investigate the evidence of ischemic susceptibility after aging and hypertension. Four groups of rat were studied: young normotensive Wistar-Kyoto (WKY) rat, aged normotensive WKY rat, young spontaneously hypertensive rat (SHR) and aged SHR. Brain images were acquired at a 3.0T Tim-Trio MRI system. For diffusion-weighted images, apparent diffusion coefficient (ADC) was measured. Relative cerebral blood flow (CBF) was also calculated. Cerebral ischemic susceptibility was examined by using ischemic model of bilateral common carotid artery occlusion. In the MRI study of non-ischemic rat, aged SHR had significantly higher ADC (P<0.01) and significantly lower CBF (P<0.01) in the parietal cortex, but aged WKY rat had only significantly lower CBF (P<0.01) when compared with young WKY rat. The ADC/CBF ratio in the parietal cortex was significantly higher in aged SHR when compared with young WKY rat, young SHR and aged WKY rat (P<0.01, P<0.05, P<0.05, respectively) suggesting a significant diffusion-perfusion disparity in aged SHR. After bilateral common carotid artery occlusion, there was significantly larger damage in the parietal cortex of aged SHR when compared with young WKY rat, young SHR and aged WKY rat (all P<0.05), but not in the hippocampus and thalamus (P> 0.05). Our study demonstrated a significantly increased ADC value and reduced CBF in the ischemia-vulnerable cortical area. This cerebral diffusion-perfusion disparity is seen mainly in aged rat and can be more evident if associated with hypertension indicating an increased susceptibility of brain tissue to ischemic injury.

AB - Aging is the most significant non-modifiable risk factor and hypertension is the most significant modifiable risk factor for ischemic stroke. We used magnetic resonance imaging (MRI) to investigate the evidence of ischemic susceptibility after aging and hypertension. Four groups of rat were studied: young normotensive Wistar-Kyoto (WKY) rat, aged normotensive WKY rat, young spontaneously hypertensive rat (SHR) and aged SHR. Brain images were acquired at a 3.0T Tim-Trio MRI system. For diffusion-weighted images, apparent diffusion coefficient (ADC) was measured. Relative cerebral blood flow (CBF) was also calculated. Cerebral ischemic susceptibility was examined by using ischemic model of bilateral common carotid artery occlusion. In the MRI study of non-ischemic rat, aged SHR had significantly higher ADC (P<0.01) and significantly lower CBF (P<0.01) in the parietal cortex, but aged WKY rat had only significantly lower CBF (P<0.01) when compared with young WKY rat. The ADC/CBF ratio in the parietal cortex was significantly higher in aged SHR when compared with young WKY rat, young SHR and aged WKY rat (P<0.01, P<0.05, P<0.05, respectively) suggesting a significant diffusion-perfusion disparity in aged SHR. After bilateral common carotid artery occlusion, there was significantly larger damage in the parietal cortex of aged SHR when compared with young WKY rat, young SHR and aged WKY rat (all P<0.05), but not in the hippocampus and thalamus (P> 0.05). Our study demonstrated a significantly increased ADC value and reduced CBF in the ischemia-vulnerable cortical area. This cerebral diffusion-perfusion disparity is seen mainly in aged rat and can be more evident if associated with hypertension indicating an increased susceptibility of brain tissue to ischemic injury.

KW - Aging

KW - Blood pressure

KW - Cerebral ischemia

KW - Magnetic resonance imaging

UR - http://www.scopus.com/inward/record.url?scp=78651421227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78651421227&partnerID=8YFLogxK

U2 - 10.1016/j.expneurol.2010.12.003

DO - 10.1016/j.expneurol.2010.12.003

M3 - Article

C2 - 21146526

AN - SCOPUS:78651421227

VL - 227

SP - 314

EP - 321

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 2

ER -