TY - JOUR
T1 - Effectiveness of Light Therapy in Cognitively Impaired Persons
T2 - A Metaanalysis of Randomized Controlled Trials
AU - Chiu, Huei Ling
AU - Chan, Pi Tuan
AU - Chu, Hsin
AU - Hsiao, Shu Tai Sheen
AU - Liu, Doresses
AU - Lin, Chueh Ho
AU - Chou, Kuei Ru
N1 - Funding Information:
This study was supported by the Ministry of Science and Technology, Taiwan. The findings and conclusions in this document are those of the authors, who are responsible for its contents.
Publisher Copyright:
© 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society
PY - 2017/10
Y1 - 2017/10
N2 - Objectives: To explore the effects of light therapy on behavioral disturbances (BDs), sleep quality, and depression. Design: Meta-analysis of randomized controlled trials. Setting: PubMed, Cochrane Library, Medline, EMBASE, Web of Science, and clinicaltrials.gov of selected randomized controlled trials and previous systematic reviews were searched. Participants: Cognitively impaired persons. Measurements: Information was extracted on study characteristics, quality assessment, and outcomes. Outcome measures included BDs, sleep quality, and depression. Results: Nine randomized controlled trials were examined. The results showed that light therapy has a moderate effect on BD (g = −0.61) and depression (g = −0.58) and a small effect on total sleep time at night (g = 0.25). Subgroup analysis indicated that a light intensity of 2,500 lux or greater has a greater effect on depression than an intensity of less than 2,500 lux (P =.03), and the low risk of bias in blinding was superior to the RCTs deemed to be of high or unclear risk of bias in blinding in terms of BD (P =.02). Conclusion: Light therapy can relieve BD, improve sleep quality, and alleviate symptoms of depression for cognitively impaired persons.
AB - Objectives: To explore the effects of light therapy on behavioral disturbances (BDs), sleep quality, and depression. Design: Meta-analysis of randomized controlled trials. Setting: PubMed, Cochrane Library, Medline, EMBASE, Web of Science, and clinicaltrials.gov of selected randomized controlled trials and previous systematic reviews were searched. Participants: Cognitively impaired persons. Measurements: Information was extracted on study characteristics, quality assessment, and outcomes. Outcome measures included BDs, sleep quality, and depression. Results: Nine randomized controlled trials were examined. The results showed that light therapy has a moderate effect on BD (g = −0.61) and depression (g = −0.58) and a small effect on total sleep time at night (g = 0.25). Subgroup analysis indicated that a light intensity of 2,500 lux or greater has a greater effect on depression than an intensity of less than 2,500 lux (P =.03), and the low risk of bias in blinding was superior to the RCTs deemed to be of high or unclear risk of bias in blinding in terms of BD (P =.02). Conclusion: Light therapy can relieve BD, improve sleep quality, and alleviate symptoms of depression for cognitively impaired persons.
KW - behavioral disturbance
KW - cognitively impaired
KW - depression
KW - light therapy
KW - sleep quality
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U2 - 10.1111/jgs.14990
DO - 10.1111/jgs.14990
M3 - Article
C2 - 28734045
AN - SCOPUS:85031492299
VL - 65
SP - 2227
EP - 2234
JO - Journal of the American Geriatrics Society
JF - Journal of the American Geriatrics Society
SN - 0002-8614
IS - 10
ER -