Effective salvage therapy of imatinib-resistant gastrointestinal stromal tumor with combination of imatinib and pegylated liposomal doxorubicin

Yao Yu Hsieh, Chueh Chuan Yen, Chun Nan Yeh, Chin Yuan Tzen, Jin Hwang Liu, Hui Ju Lee, Hao Wei Teng, Cheng Hwai Tzeng, Tzeon Jye Chiou, Ta Chung Chao

研究成果: 雜誌貢獻文章

1 引文 (Scopus)

摘要

Here we presented a 60-year-old Taiwanese man with advanced gastrointestinal stromal tumor. Disease progression was noted during imatinib treatment. Surgical resection was done and mutation analysis of KIT gene in all the resected tumors revealed deletion mutations of codons 558-565 in exon 11, whereas a missense mutation was also identified at codon 822 in exon 17 in one resected tumor. Patient's disease was refractory to escalating dose of imatinib and dasatinb. Surprisingly, combination of imatinib with pegylated liposomal doxorubicin produced a substantial response and resulted in a 5-month progression free period for this imatinib-resistant gastrointestinal stromal tumor.

原文英語
頁(從 - 到)272-274
頁數3
期刊Journal of the Chinese Medical Association
74
發行號6
DOIs
出版狀態已發佈 - 六月 2011
對外發佈Yes

指紋

Salvage Therapy
Gastrointestinal Stromal Tumors
Codon
Exons
Sequence Deletion
Missense Mutation
Disease Progression
Neoplasms
Mutation
liposomal doxorubicin
Imatinib Mesylate
Genes
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

引用此文

Effective salvage therapy of imatinib-resistant gastrointestinal stromal tumor with combination of imatinib and pegylated liposomal doxorubicin. / Hsieh, Yao Yu; Yen, Chueh Chuan; Yeh, Chun Nan; Tzen, Chin Yuan; Liu, Jin Hwang; Lee, Hui Ju; Teng, Hao Wei; Tzeng, Cheng Hwai; Chiou, Tzeon Jye; Chao, Ta Chung.

於: Journal of the Chinese Medical Association, 卷 74, 編號 6, 06.2011, p. 272-274.

研究成果: 雜誌貢獻文章

Hsieh, Yao Yu ; Yen, Chueh Chuan ; Yeh, Chun Nan ; Tzen, Chin Yuan ; Liu, Jin Hwang ; Lee, Hui Ju ; Teng, Hao Wei ; Tzeng, Cheng Hwai ; Chiou, Tzeon Jye ; Chao, Ta Chung. / Effective salvage therapy of imatinib-resistant gastrointestinal stromal tumor with combination of imatinib and pegylated liposomal doxorubicin. 於: Journal of the Chinese Medical Association. 2011 ; 卷 74, 編號 6. 頁 272-274.
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AU - Tzen, Chin Yuan

AU - Liu, Jin Hwang

AU - Lee, Hui Ju

AU - Teng, Hao Wei

AU - Tzeng, Cheng Hwai

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