Effect of Z,E-butylidedephthalide on experimental choroidal neovascularization in rat and ocular blood flow in rabbits

Wei Jiang, Wun Chang Ko, Shu Huei Hsiao, George C Y Chiou

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

• Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P
原文英語
頁(從 - 到)1-5
頁數5
期刊International Eye Science
7
發行號1
出版狀態已發佈 - 二月 2007

ASJC Scopus subject areas

  • 眼科

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