摘要
• Aim: To investigate the effect of Z,E-butylidedephthalide (Bdph) on laser-induced experimental choroidal neovascularization (CNV) in rat model and choroid blood flow in rabbits' eyes. • Methods: Male Brown Norway rats were treated with Nd: YAG laser to break Bruch's membrane. Thirty mg/kg and 15 mg/kg Bdph were given daily through intraperitoneal injection for 4 weeks after laser treatment. Fluorescein angiography (FA) and choroidal flat mount were used to measure the development of CNV. Female New Zealand white rabbits' eyes were instilled with 10g/L ZE-butylidenephthalide solution,and ocular blood flow was measured with colored microsphere technique. • Results: The intensity of fluorescein leakage, indicating the ocular lesion, decreased significantly in group Bdph 30mg/kg and 15mg/kg, as compared to the control at P
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 1-5 |
| 頁數 | 5 |
| 期刊 | International Eye Science |
| 卷 | 7 |
| 發行號 | 1 |
| 出版狀態 | 已發佈 - 2月 2007 |
ASJC Scopus subject areas
- 眼科