摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 131-136 |
| 頁數 | 6 |
| 期刊 | Journal of Affective Disorders |
| 卷 | 201 |
| DOIs | |
| 出版狀態 | 已發佈 - 九月 1 2016 |
指紋
ASJC Scopus subject areas
- Psychiatry and Mental health
- Clinical Psychology
引用此文
Effect of valproic acid on dementia onset in patients with bipolar disorder. / Tsai, Pei-Shan; Liu, I-Chao; Chiu, Chen Huan; Huang, Chun Jen; Wang, Mei Yeh.
於: Journal of Affective Disorders, 卷 201, 01.09.2016, p. 131-136.研究成果: 雜誌貢獻 › 文章
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TY - JOUR
T1 - Effect of valproic acid on dementia onset in patients with bipolar disorder
AU - Tsai, Pei-Shan
AU - Liu, I-Chao
AU - Chiu, Chen Huan
AU - Huang, Chun Jen
AU - Wang, Mei Yeh
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. This study investigated the effect of VPA on the risk of dementia in patients with bipolar disorder. Methods We analyzed data from Taiwan's Longitudinal Health Insurance Database 2010. Patients with bipolar disorder who were prescribed VPA for 28 days or at least once per month for 3 consecutive months after the index date were classified as the VPA-treated group, whereas those who did not receive VPA were classified as the VPA-untreated group. Both groups were tracked until the end of 2013 or until loss to follow-up to identify new-onset dementia events. Multivariable Cox proportional hazards models were used to estimate the hazard ratio (HR) of subsequent dementia associated with VPA treatment after adjustment for confounding variables. Results The study comprised 5158 patients with bipolar disorder. The multivariable-adjusted HR for newly diagnosed dementia was 1.73 (95% confidence interval [CI], 1.24-2.41, P=0.001) for the VPA-treated group compared with the VPA-untreated group after adjustment for potential confounders. The VPA-treated group had a higher risk than did the VPA-untreated group after propensity score adjustment (HR=1.95, 95% CI=1.42-2.67, P
AB - Background Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. This study investigated the effect of VPA on the risk of dementia in patients with bipolar disorder. Methods We analyzed data from Taiwan's Longitudinal Health Insurance Database 2010. Patients with bipolar disorder who were prescribed VPA for 28 days or at least once per month for 3 consecutive months after the index date were classified as the VPA-treated group, whereas those who did not receive VPA were classified as the VPA-untreated group. Both groups were tracked until the end of 2013 or until loss to follow-up to identify new-onset dementia events. Multivariable Cox proportional hazards models were used to estimate the hazard ratio (HR) of subsequent dementia associated with VPA treatment after adjustment for confounding variables. Results The study comprised 5158 patients with bipolar disorder. The multivariable-adjusted HR for newly diagnosed dementia was 1.73 (95% confidence interval [CI], 1.24-2.41, P=0.001) for the VPA-treated group compared with the VPA-untreated group after adjustment for potential confounders. The VPA-treated group had a higher risk than did the VPA-untreated group after propensity score adjustment (HR=1.95, 95% CI=1.42-2.67, P
KW - Bipolar disorder
KW - Dementia
KW - Mood stabilizers
KW - Valproic acid
UR - http://www.scopus.com/inward/record.url?scp=84969263023&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84969263023&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2016.05.010
DO - 10.1016/j.jad.2016.05.010
M3 - Article
C2 - 27208500
AN - SCOPUS:84969263023
VL - 201
SP - 131
EP - 136
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -